NCI-H1819Homo sapiens (Human)Cancer cell line
Also known as: NCIH1819, H-1819, H1819
Quick Overview
Human lung cancer cell line with known mutations in TP53 and CDKN2A.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1497 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Lung adenocarcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Lung Adenocarcinoma |
| OncoTree Code | LUAD |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000033_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | c.993+1G>T (IVS9+1G>T) | Unspecified | Splice donor mutation | PubMed=31541927, PubMed=23613873, PubMed=18487078, PubMed=18006756, PubMed=16203773, PubMed=15287027 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
Aldige C.R., Wistuba I.I., Minna J.D.
J. Cell. Biochem. 121:3986-3999(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Posner B.A., Minna J.D., Kim H.S., White M.A.
Cell 173:864-878.e29(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Heymach J.V.
Cancer Discov. 2:798-811(2012).
Lung cancer cell lines as tools for biomedical discovery and research.
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
J. Natl. Cancer Inst. 102:1310-1321(2010).
MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.
Gazdar A.F., Pertsemlidis A.
J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010).
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.
Cancer Sci. 101:1891-1896(2010).
A gene-alteration profile of human lung cancer cell lines.";
Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
Hum. Mutat. 30:1199-1206(2009).
High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.
Gazdar A.F., Lam S., MacAulay C., Lam W.L.
Int. J. Cancer 118:1556-1564(2006).
Short tandem repeat profiling provides an international reference standard for human cell lines.
Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Minna J.D.
Oncogene 20:1005-1009(2001).
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.
Oncogene 19:4632-4639(2000).
Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.
Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.
Cancer Res. 60:4894-4906(2000).
Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types.
Minna J.D., Gazdar A.F.
Genes Chromosomes Cancer 21:308-319(1998).