NCI-H1836Homo sapiens (Human)Cancer cell line

Also known as: NCIH1836, H-1836, H1836

🤖 AI SummaryBased on 7 publications

Quick Overview

Human small cell lung cancer cell line with known MYC amplification and drug sensitivity profiles.

Detailed Summary

The NCI-H1836 cell line is a human small cell lung cancer (SCLC) cell line derived from a patient with extensive stage disease. It is characterized by MYC family DNA amplification, which is associated with aggressive tumor behavior and resistance to certain chemotherapeutic agents. This cell line has been used in studies investigating the molecular mechanisms of SCLC, including the role of MYC amplification in tumor progression and drug response. Research has shown that NCI-H1836 exhibits specific patterns of gene expression and protein activation that differentiate it from non-small cell lung cancer (NSCLC) cell lines, making it a valuable model for studying SCLC biology and developing targeted therapies. The cell line has also been utilized in drug sensitivity profiling to identify potential therapeutic agents for SCLC treatment.

Research Applications

Molecular mechanisms of SCLC progressionMYC amplification in tumor biologyDrug sensitivity profiling for SCLCComparative analysis with NSCLC cell lines

Key Characteristics

MYC family DNA amplificationSmall cell lung cancer originExtensive stage disease associationDrug response profiling

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1498
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	52
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-000559_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gly244Cys (c.730G>T)	Unspecified	-	PubMed=28273451, PubMed=22931248
MutationSimple	ALK	p.Arg1496Glufs*27 (c.4485delC) (p.S1495fs)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

10,12

D16S539

11,13

D18S51

D19S433

14,16.2

D21S11

D2S1338

20,23

D3S1358

D5S818

D7S820

11,12

D8S1179

FGA

24,26

Penta D

10,12

Penta E

TH01

8,9.3

TPOX

9,10

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Heymach J.V.

Cancer Discov. 2:798-811(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

DOI PubMed

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

Ihde D.C., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:210-217(1996).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Web Resources

tcpaportal.org