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NCI-H1838Homo sapiens (Human)Cancer cell line

Also known as: NCIH1838, H-1838, H1838

🤖 AI SummaryBased on 9 publications

Quick Overview

Human lung cancer cell line with known RB gene status and potential for drug sensitivity studies.

Detailed Summary

The NCI-H1838 cell line is a human lung cancer cell line derived from a non-small cell lung cancer (NSCLC) tumor. It is characterized by the presence of wild-type RB (retinoblastoma) protein, indicating that the RB gene is not inactivated in this cell line. This makes it a valuable model for studying the role of RB in lung cancer biology and for investigating therapeutic strategies that target RB-related pathways. The cell line has been included in large-scale genomic and transcriptomic studies, providing insights into its genetic and molecular profile. These studies have identified potential targets for drug development and have contributed to the understanding of lung cancer heterogeneity. The NCI-H1838 cell line is also part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in research to predict drug sensitivity and resistance.

Research Applications

RB gene function studiesDrug sensitivity profilingGenomic and transcriptomic analysisCancer heterogeneity research

Key Characteristics

Wild-type RB proteinPart of CCLEUsed in drug sensitivity studies

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1499
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age Category	Unknown
Sex	Female

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000733_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273Leu (c.818G>T)	Homozygous	Somatic mutation acquired during proliferation	PubMed=31541927, PubMed=23613873, PubMed=15735012
MutationSimple	NF1	p.Asn184fs*17 (c.548_549insA)	Heterozygous	-	Unknown, Unknown
MutationSimple	ATM	p.Trp1279Ter (c.3836G>A)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

12

D13S317

11

D16S539

13

D18S51

17

D19S433

15

D21S11

29

D2S1338

19,20

D3S1358

15

D5S818

12

D7S820

8

D8S1179

14

FGA

20,23.2

Penta D

9,13

Penta E

12

TH01

8

TPOX

8

vWA

17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

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