NCI-H1882Homo sapiens (Human)Cancer cell line

Also known as: H-1882, H1882

🤖 AI SummaryBased on 7 publications

Quick Overview

Human lung cancer cell line with known RB mutations and potential for cancer research.

Detailed Summary

The NCI-H1882 cell line is a human lung cancer cell line derived from a patient with small cell lung cancer. It is characterized by mutations in the RB gene, which is a key tumor suppressor gene involved in cell cycle regulation. This cell line has been extensively studied for its role in understanding the genetic and molecular mechanisms underlying lung cancer progression. The presence of RB mutations suggests a potential for research into the development of targeted therapies. Additionally, the cell line has been used in studies examining the role of viral sequences and gene fusions in cancer development. The NCI-H1882 cell line is part of a comprehensive collection of cancer cell lines that have been utilized in numerous research studies and clinical trials.

Research Applications

Cancer genetics and molecular mechanismsRB gene mutations and tumor suppressionViral sequence integration in cancerGene fusion analysis

Key Characteristics

RB gene mutationsSmall cell lung cancer originPotential for targeted therapy research

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1504
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	59
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-002490_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

D18S51

D19S433

13,14

D21S11

D2S1338

D3S1358

D5S818

D7S820

10,12

D8S1179

12,14

FGA

21,24

Penta D

12,13

Penta E

TH01

TPOX

8,9

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

DOI PubMed

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

Ihde D.C., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:210-217(1996).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed