NCI-H1915Homo sapiens (Human)Cancer cell line

Also known as: NCIH1915, H-1915, H1915

🤖 AI SummaryBased on 8 publications

Quick Overview

Human lung cancer cell line with potential for drug sensitivity studies.

Detailed Summary

The NCI-H1915 cell line is a human lung cancer cell line derived from a patient with non-small cell lung cancer. It is widely used in cancer research for studying the molecular mechanisms of tumorigenesis and for evaluating the efficacy of anticancer drugs. This cell line has been characterized for its genetic and molecular profiles, making it a valuable tool for preclinical studies. Research on NCI-H1915 has contributed to understanding the role of specific genes and pathways in cancer progression and therapeutic response.

Research Applications

Cancer biology researchDrug sensitivity studiesMolecular mechanism investigations

Key Characteristics

Human lung cancer cell lineUsed in preclinical drug testingCharacterized for genetic and molecular profiles
Generated on 6/17/2025

Basic Information

Database IDCVCL_1505
SpeciesHomo sapiens (Human)
Tissue SourceLung[UBERON:UBERON_0002048]

Donor Information

Age61
Age CategoryAdult
SexFemale
Racecaucasian

Disease Information

DiseaseLung non-small cell carcinoma
LineageLung
SubtypeLarge Cell Lung Carcinoma
OncoTree CodeLCLC

DepMap Information

Source TypeATCC
Source IDACH-000434_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Lys291Ter (c.871A>T)Unspecified-PubMed=19147553
MutationSimpleHRASp.Gln61Leu (c.182A>T)Unspecified-from parent cell line KYSE-30
MutationSimpleCDKN2Ap.Phe90Leu (c.270C>G)Homozygous-Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11
D13S317
11
D16S539
9
D18S51
11
D19S433
13,14
D21S11
27
D2S1338
17,24
D3S1358
15,18
D5S818
12
D7S820
11,12
D8S1179
10
FGA
20
Penta D
13
Penta E
10
TH01
6,9
TPOX
8,11
vWA
15,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Comparative proteome analysis across non-small cell lung cancer cell lines.

Daub H.

J. Proteomics 130:1-10(2016).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Lung cancer cell lines as tools for biomedical discovery and research.

Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.

J. Natl. Cancer Inst. 102:1310-1321(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.

Gazdar A.F.

Oncogene 7:171-180(1992).