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NCI-H1963Homo sapiens (Human)Cancer cell line

Also known as: NCIH1963, H-1963, H1963

🤖 AI SummaryBased on 12 publications

Quick Overview

Human small cell lung cancer cell line with known genetic alterations.

Detailed Summary

The NCI-H1963 cell line is a human small cell lung cancer (SCLC) cell line derived from a patient with metastatic disease. It is widely used in research to study the molecular mechanisms of SCLC, including the role of genetic alterations in tumor progression and drug resistance. This cell line has been characterized for its sensitivity to Bcl-2 inhibitors and has been involved in studies related to chromosomal abnormalities and gene expression profiles. Research on NCI-H1963 has contributed to understanding the genetic basis of SCLC and the development of targeted therapies.

Research Applications

Genomic analysis of small cell lung cancerDrug sensitivity profilingBcl-2 inhibitor sensitivityChromosomal abnormalities in SCLCGene expression profiling

Key Characteristics

Sensitivity to Bcl-2 inhibitorsKnown genetic alterations in SCLCUsed in studies of tumor progression and drug resistance

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1510
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	56
Age Category	Adult
Sex	Male
Race	black_or_african_american

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-000729_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.His214Arg (c.641A>G)	Unspecified	-	Unknown
MutationSimple	TP53	p.Val147Asp (c.440T>A)	Unspecified	-	PubMed=32321971
MutationSimple	RB1	p.Cys61Ter (c.183T>A)	Homozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

12

D13S317

11,13

D16S539

11

D18S51

17,18,19

D19S433

13,14

D21S11

30,31

D2S1338

20,24

D3S1358

15

D5S818

12

D7S820

10,12

D8S1179

10,11

FGA

21,24

Penta D

9,11

Penta E

5,13

TH01

6,8

TPOX

8,10

vWA

17,20

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.

Yokota J.

Genes Chromosomes Cancer 52:802-816(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.

Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.

Cancer Sci. 101:1891-1896(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

A gene-alteration profile of human lung cancer cell lines.";

Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.

Hum. Mutat. 30:1199-1206(2009).

Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.

Sauter G., Lesniewski R., Semizarov D.

Mol. Cancer Res. 5:331-339(2007).

Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.

Minna J.D.

Oncogene 20:1005-1009(2001).

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.

Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.

Cancer Res. 60:4894-4906(2000).

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

Ihde D.C., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:210-217(1996).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.

Gazdar A.F., Minna J.D.

Oncogene 7:339-346(1992).

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