NCI-H2029Homo sapiens (Human)Cancer cell line

Also known as: NCIH2029, H-2029, H2029

🤖 AI SummaryBased on 7 publications

Quick Overview

Human lung cancer cell line with known RB mutations and potential for drug sensitivity studies.

Detailed Summary

The NCI-H2029 cell line is a human lung cancer cell line derived from a patient with small cell lung cancer. It is characterized by mutations in the RB gene, which is a key tumor suppressor gene involved in cell cycle regulation. This cell line has been used in studies examining the role of RB-related genes and SV40 large T antigen in cancer development. Research has shown that NCI-H2029 exhibits specific patterns of protein expression and genetic alterations that may influence its response to anticancer drugs. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been utilized in predictive modeling of drug sensitivity. Its genetic profile makes it a valuable resource for studying the molecular mechanisms of lung cancer and developing targeted therapies.

Research Applications

RB gene mutation analysisDrug sensitivity profilingCancer cell line encyclopedia (CCLE)SV40 large T antigen studies

Key Characteristics

RB gene mutationsSmall cell lung cancer originPart of CCLE databasePotential for drug response studies

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1516
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	69
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-000298_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr220Asp (c.658T>G)	Unspecified	-	PubMed=27693639
MutationSimple	RB1	c.265-1G>T	Homozygous	Splice acceptor mutation	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11

D13S317

11,14

D16S539

D18S51

D19S433

14,15

D21S11

30,31.2

D2S1338

17,22

D3S1358

16,17

D5S818

10,11

D7S820

9,11

D8S1179

11,15

FGA

21,25

Penta D

Penta E

TH01

7,9.3

TPOX

vWA

15,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Lung cancer cell lines as tools for biomedical discovery and research.

Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.

J. Natl. Cancer Inst. 102:1310-1321(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

DOI PubMed

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

Ihde D.C., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:210-217(1996).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed