NCI-H2052Homo sapiens (Human)Cancer cell line

Also known as: NCIH2052, H2052_MM, H-2052, H2052

🤖 AI SummaryBased on 13 publications

Quick Overview

Human malignant mesothelioma cell line with known genetic alterations.

Detailed Summary

The NCI-H2052 cell line is a human malignant mesothelioma cell line derived from pleural tissue. It is widely used in research to study the molecular mechanisms of mesothelioma, particularly focusing on genetic alterations and their implications in cancer progression. This cell line has been implicated in studies related to the Hippo signaling pathway, BAP1 mutations, and other genetic factors contributing to mesothelioma development. Research on NCI-H2052 has provided insights into the role of tumor suppressor genes and their inactivation in mesothelioma, offering potential targets for therapeutic interventions.

Research Applications

Hippo signaling pathway studiesBAP1 mutation analysisGenetic alterations in mesotheliomaTumor suppressor gene inactivation

Key Characteristics

Known mutations in BAP1Involvement in Hippo pathway researchUsed for studying mesothelioma genetics
Generated on 6/17/2025

Basic Information

Database IDCVCL_1518
SpeciesHomo sapiens (Human)
Tissue SourcePleural effusion[UBERON:UBERON_0000175]

Donor Information

Age65
Age CategoryAdult
SexMale
Racecaucasian

Disease Information

DiseasePleural mesothelioma
LineagePleura
SubtypePleural Mesothelioma, Sarcomatoid Type
OncoTree CodePLSMESO

DepMap Information

Source TypeATCC
Source IDACH-000153_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationNone reportedTP53---PubMed=19787792
MutationSimpleTERTc.1-124C>T (c.228C>T) (C228T)UnspecifiedIn promoterfrom parent cell line Hep-G2
MutationSimpleRASSF2p.Glu294Ter (c.880G>T)Heterozygous-Unknown, PubMed=25902174
MutationSimpleNF2p.Arg341Ter (c.1021C>T)Homozygous-Unknown, Unknown, PubMed=25902174, PubMed=16630136
Gene deletionLATS2-Homozygous-PubMed=21245096
Gene deletionCDKN2A-HomozygousPossiblePubMed=26870271

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10,11
D13S317
12
D16S539
11,13
D18S51
16,17
D19S433
12,15
D21S11
32.2
D2S1338
17,18
D3S1358
14,15
D5S818
11
D7S820
11,12
D8S1179
13
FGA
24
Penta D
10
Penta E
12,16
TH01
7,9.3
TPOX
8
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in merlin-negative malignant mesothelioma cells.

Kato T., Sato T., Yokoi K., Sekido Y.

Oncogene 36:5522-5531(2017).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.

Yokoi K., Sekido Y.

Cancer Sci. 106:990-999(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.

Asamura H., Gemma A., Yamada T.

J. Thorac. Oncol. 10:844-851(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma.

Rice D.C., Tsao A., Wistuba I.I.

J. Thorac. Oncol. 9:998-1007(2014).

Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.

Meltzer P.S., Kirsch I.R., Kaye F.J., Roschke A.V.

Cancer Genet. 206:191-205(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.

Powell S.N., Zhou Q., Shen R.-L., Olshen A.B., Rusch V.W., Ladanyi M.

Nat. Genet. 43:668-672(2011).

LATS2 is a tumor suppressor gene of malignant mesothelioma.";

Sekido Y.

Cancer Res. 71:873-883(2011).

MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.

Gazdar A.F., Pertsemlidis A.

J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Combined treatment with cisplatin and sirolimus to enhance cell death in human mesothelioma.

Hartman M.-L., Esposito J.M., Yeap B.Y., Sugarbaker D.J.

J. Thorac. Cardiovasc. Surg. 139:1233-1240(2010).

Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.

Sekido Y.

Cancer Sci. 98:438-446(2007).

Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients.

Yokoi K., Horio Y., Shimokata K., Sekido Y., Hida T.

Cancer Sci. 97:387-394(2006).

Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.

Minna J.D.

Oncogene 20:1005-1009(2001).

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.

Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.

Cancer Res. 60:4894-4906(2000).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

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