NCI-H2073Homo sapiens (Human)Cancer cell line

Also known as: NCIH2073, H-2073, H2073

🤖 AI SummaryBased on 8 publications

Quick Overview

Human cancer cell line with known mutations and drug resistance profiles.

Detailed Summary

The NCI-H2073 cell line is a human-derived cancer cell line with documented mutations and drug resistance characteristics. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been studied for its genetic and molecular profiles. Research indicates that it exhibits specific mutations in genes such as TP53 and STK11, which are associated with cancer progression and therapeutic resistance. The cell line has been used in studies to understand the mechanisms of drug resistance and to identify potential therapeutic targets. It is also part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its gene expression and copy number variations. The cell line is used in studies related to small cell lung cancer and has been involved in research on the role of PARP1 and other genes in cancer progression.

Research Applications

Cancer researchDrug resistance studiesGenomic profilingTherapeutic target identification

Key Characteristics

Mutations in TP53 and STK11Drug resistance profilesGene expression analysisCopy number variations

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1521
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	47
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000590_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys242Trp (c.726C>G)	Homozygous	-	Unknown, PubMed=1311061

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D18S51

13,17.3

D19S433

13,15

D21S11

D2S1338

17,23

D3S1358

D5S818

D7S820

D8S1179

12,14

FGA

22,23

Penta D

Penta E

TH01

6,9.3

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Integrative analysis of two cell lines derived from a non-small-lung cancer patient -- a panomics approach.

Li R.-Q., Minna J.D., Li Y.-R., Shames D.S., Zhang Z.-M.

Pac. Symp. Biocomput. 2014:75-86(2014).

DOI PubMed PMC

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Heymach J.V.

Cancer Discov. 2:798-811(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.

Gazdar A.F.

Oncogene 7:171-180(1992).

PubMed

Web Resources

tcpaportal.org