NCI-H2085Homo sapiens (Human)Cancer cell line

Also known as: NCIH2085, H-2085, H2085

🤖 AI SummaryBased on 6 publications

Quick Overview

Human small cell lung cancer cell line with high PARP1 expression.

Detailed Summary

NCI-H2085 is a human small cell lung cancer (SCLC) cell line characterized by high expression of PARP1, a key protein involved in DNA repair and cell survival. This cell line is frequently used in research to study the role of PARP1 in SCLC and its potential as a therapeutic target. Studies have shown that NCI-H2085 exhibits sensitivity to PARP inhibitors, making it a valuable model for investigating targeted therapies. The cell line's molecular profile includes dysregulated pathways such as the Rb/E2F1 pathway and DNA repair mechanisms, which are critical in understanding SCLC biology and developing effective treatments.

Research Applications

Small cell lung cancer researchPARP1 inhibition studiesDNA repair mechanismsDrug sensitivity profiling

Key Characteristics

High PARP1 expressionSensitivity to PARP inhibitorsDysregulated Rb/E2F1 pathwayAltered DNA repair mechanisms

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1523
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	45
Age Category	Adult
Sex	Male

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000451_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr220Cys (c.659A>G)	Unspecified	-	PubMed=21173094
MutationSimple	SMARCA4	p.Glu463Ter (c.1387G>T)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

11,12

D16S539

D18S51

16,17

D19S433

14,16

D21S11

24.2,29

D2S1338

D3S1358

14,16

D5S818

D7S820

D8S1179

FGA

Penta D

10,13

Penta E

10,15

TH01

9.3

TPOX

vWA

15,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Heymach J.V.

Cancer Discov. 2:798-811(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Web Resources

tcpaportal.org