NCI-H209Homo sapiens (Human)Cancer cell line
Also known as: H209, H-209, NCIH209
Quick Overview
Small cell lung cancer cell line with known genetic alterations
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1525 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Lung small cell carcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Small Cell Lung Cancer |
| OncoTree Code | SCLC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000290_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | RB1 | p.Cys706Phe (c.2117G>T) | Homozygous | - | Unknown, Unknown, Unknown |
| MutationSimple | TP53 | c.673-2A>T (IVS6-2A>T) | Unspecified | Splice acceptor mutation | PubMed=11799138 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Neuromedin B is present in lung cancer cell lines.";
Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.
Cancer Res. 52:2732s-2736s(1992).
Establishment and identification of small cell lung cancer cell lines having classic and variant features.
Moody T.W., Zweig M.H., Minna J.D.
Cancer Res. 45:2913-2923(1985).
Cytogenetics of human small cell lung cancer.";
Whang-Peng J., Lee E.C.
Recent Results Cancer Res. 97:37-46(1985).
Heterogeneity in the radiation survival curves and biochemical properties of human lung cancer cell lines.
Mitchell J.B.
J. Natl. Cancer Inst. 73:801-807(1984).
Monoclonal antibodies that demonstrate specificity for several types of human lung cancer.
Cuttitta F., Rosen S.T., Gazdar A.F., Minna J.D.
Proc. Natl. Acad. Sci. U.S.A. 78:4591-4595(1981).
High levels of intracellular bombesin characterize human small-cell lung carcinoma.
Moody T.W., Pert C.B., Gazdar A.F., Carney D.N., Minna J.D.
Science 214:1246-1248(1981).
Analysis of human small cell lung cancer differentiation antigens using a panel of rat monoclonal antibodies.
Gazdar A.F., Minna J.D.
Cancer Res. 44:2052-2061(1984).
Secretion of atrial natriuretic peptide and vasopressin by small cell lung cancer.
Lofters W.S., Flynn T.G.
Cancer 75:2442-2451(1995).
Insulin-like growth factor expression in human cancer cell lines.";
Grimley C., Battey J., Mulshine J.L., Cuttitta F.
J. Biol. Chem. 271:11477-11483(1996).
NCI-Navy Medical Oncology Branch cell line data base.";
Carney D.N., Minna J.D., Mulshine J.L.
J. Cell. Biochem. Suppl. 24:32-91(1996).
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
Ihde D.C., Gazdar A.F.
J. Cell. Biochem. Suppl. 24:210-217(1996).
Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types.
Minna J.D., Gazdar A.F.
Genes Chromosomes Cancer 21:308-319(1998).
Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma.
Rabbitts P.H., Sundaresan V., Hofstra R.M.W., Eng C.
Genes Chromosomes Cancer 21:326-332(1998).
Expression of the MRP and MDR1 multidrug resistance genes in small cell lung cancer.
Cole S.P.C., Gerlach J.H.
Clin. Cancer Res. 3:115-122(1997).
Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma.
Tang X.X., Brodeur G.M., Campling B.G., Ikegaki N.
Clin. Cancer Res. 5:455-460(1999).
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.
Int. J. Oncol. 15:927-934(1999).
Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.
Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.
Cancer Res. 60:4894-4906(2000).
Mutation and expression of the DCC gene in human lung cancer.";
Yokota J.
Neoplasia 2:300-305(2000).
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.
Oncogene 19:4632-4639(2000).
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Minna J.D.
Oncogene 20:1005-1009(2001).
High-resolution analysis of DNA copy number using oligonucleotide microarrays.
Weber B., Shapero M.H., Wooster R.
Genome Res. 14:287-295(2004).
Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping.
Grigorova M., Lyman R.C., Caldas C., Edwards P.A.W.
Cancer Genet. Cytogenet. 162:1-9(2005).
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.
Sauter G., Lesniewski R., Semizarov D.
Mol. Cancer Res. 5:331-339(2007).
A gene-alteration profile of human lung cancer cell lines.";
Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
Hum. Mutat. 30:1199-1206(2009).
A small-cell lung cancer genome with complex signatures of tobacco exposure.
Stratton M.R., Futreal P.A., Campbell P.J.
Nature 463:184-190(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.
Cancer Sci. 101:1891-1896(2010).
MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.
Gazdar A.F., Pertsemlidis A.
J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Heymach J.V.
Cancer Discov. 2:798-811(2012).
Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.
Yokota J.
Genes Chromosomes Cancer 52:802-816(2013).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
Aldige C.R., Wistuba I.I., Minna J.D.
J. Cell. Biochem. 121:3986-3999(2020).