NCI-H2106Homo sapiens (Human)Cancer cell line

Also known as: NCIH2106, H-2106, H2106, NCI H2106

🤖 AI SummaryBased on 7 publications

Quick Overview

Human lung cancer cell line with known RB and RBL2 status.

Detailed Summary

NCI-H2106 is a human lung cancer cell line derived from a patient with small cell lung cancer (SCLC). It is characterized by the presence of wildtype RB protein and the absence of RBL2 protein expression, as reported in multiple studies. This cell line has been used in research to investigate the role of RB-related genes in lung cancer progression and drug sensitivity. The cell line is part of the NCI-60 panel and has been extensively studied for its genomic and transcriptomic profiles. It is also included in large-scale cancer cell line databases such as the Cancer Cell Line Encyclopedia (CCLE) and the Catalogue of Somatic Mutations in Cancer (COSMIC).

Research Applications

Investigation of RB-related gene function in lung cancerDrug sensitivity profilingGenomic and transcriptomic analysis

Key Characteristics

Wildtype RB protein expressionAbsence of RBL2 protein expressionPart of the NCI-60 panel

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1526
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	58
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Lung large cell carcinoma
Lineage	Lung
Subtype	Large Cell Lung Carcinoma
OncoTree Code	LCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-000904_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Trp (c.742C>T)	Homozygous	Somatic mutation acquired during proliferation	from parent cell line VCaP
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,13

D13S317

D16S539

12,13

D18S51

14,16

D19S433

13,14

D21S11

30,32.2

D2S1338

17,23

D3S1358

15,17

D5S818

11,12

D7S820

D8S1179

13,14

FGA

Penta D

9,10

Penta E

7,12

TH01

TPOX

vWA

18,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Lung cancer cell lines as tools for biomedical discovery and research.

Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.

J. Natl. Cancer Inst. 102:1310-1321(2010).

DOI PubMed PMC

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.

Linnoila R.I.

Oncogene 7:743-749(1992).

PubMed

Web Resources

tcpaportal.org