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NCI-H211Homo sapiens (Human)Cancer cell line

Also known as: NCIH211, H-211, H211

🤖 AI SummaryBased on 8 publications

Quick Overview

Human small cell lung cancer cell line with Bcl-2 amplification

Detailed Summary

NCI-H211 is a human small cell lung cancer (SCLC) cell line derived from a patient with extensive stage disease. It is characterized by an amplification of the 18q21-23 chromosomal region, which includes the Bcl-2 and NOXA genes. This amplification is associated with sensitivity to Bcl-2 family inhibitors like ABT-737. The cell line exhibits a wildtype RB protein status, suggesting intact tumor suppressor function. NCI-H211 is commonly used in research to study mechanisms of drug sensitivity and resistance in SCLC, particularly in the context of Bcl-2-targeted therapies. Its genomic profile makes it a valuable model for investigating the role of Bcl-2 in cancer progression and therapeutic response.

Research Applications

Drug sensitivity profilingBcl-2 family inhibitor testingGenomic analysis of SCLCMechanisms of apoptosis regulation

Key Characteristics

Amplification of 18q21-23 regionBcl-2 and NOXA gene overexpressionWildtype RB protein statusSensitivity to ABT-737

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1529
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	50
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-000639_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Gln (c.743G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=20575032

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

12

D13S317

9

D16S539

13

D18S51

14

D19S433

12,16

D21S11

30

D2S1338

20

D3S1358

18

D5S818

11

D7S820

10,12

D8S1179

12,14

FGA

22

Penta D

9,13

Penta E

12,15

TH01

6

TPOX

11

vWA

14,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Proteomic profiling of human small cell lung cancer cell line NCI-H211.

Cho H.Y., Kim M.K., Yoo Y.D., Ahn M.J., Jang J.S.

Cancer Res. Treat. 35:489-496(2003).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.

Sauter G., Lesniewski R., Semizarov D.

Mol. Cancer Res. 5:331-339(2007).

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

Ihde D.C., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:210-217(1996).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

Cytogenetics of human small cell lung cancer.";

Whang-Peng J., Lee E.C.

Recent Results Cancer Res. 97:37-46(1985).

Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties.

Gazdar A.F., Carney D.N., Nau M.M., Minna J.D.

Cancer Res. 45:2924-2930(1985).

Establishment and identification of small cell lung cancer cell lines having classic and variant features.

Moody T.W., Zweig M.H., Minna J.D.

Cancer Res. 45:2913-2923(1985).

Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.

Linnoila R.I.

Oncogene 7:743-749(1992).

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.

Gazdar A.F., Minna J.D.

Oncogene 7:339-346(1992).

Web Resources

tcpaportal.org atcc.org