NCI-H2110Homo sapiens (Human)Cancer cell line

Also known as: NCIH2110, H-2110, H2110

🤖 AI SummaryBased on 6 publications

Quick Overview

Human cancer cell line with diverse applications in cancer research.

Detailed Summary

The NCI-H2110 cell line is a human-derived cancer cell line used in various research applications. It is part of a comprehensive collection of cancer cell lines that have been extensively characterized for their genomic and transcriptomic profiles. These cell lines are valuable for studying cancer biology, drug sensitivity, and therapeutic responses. The NCI-H2110 cell line is particularly noted for its utility in understanding the molecular mechanisms of cancer and for developing targeted therapies. Its detailed characterization includes information on genetic mutations, gene expression, and protein profiles, making it a key resource for cancer research.

Research Applications

Cancer biology researchDrug sensitivity studiesTherapeutic response analysis

Key Characteristics

Genomic and transcriptomic profilingMutation analysisGene expression profiling
Generated on 6/17/2025

Basic Information

Database IDCVCL_1530
SpeciesHomo sapiens (Human)
Tissue SourcePleural effusion[UBERON:UBERON_0000175]

Donor Information

Age CategoryUnknown
SexUnknown

Disease Information

DiseaseLung non-small cell carcinoma
LineageLung
SubtypeNon-Small Cell Lung Cancer
OncoTree CodeNSCLC

DepMap Information

Source TypeATCC
Source IDACH-000929_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12
D13S317
12
D16S539
11
D18S51
16
D19S433
14,14.2
D21S11
30
D2S1338
17,25
D3S1358
16
D5S818
12
D7S820
8,11
D8S1179
14
FGA
22,24
Penta D
9,11
Penta E
8,13
TH01
9
TPOX
8,11
vWA
15,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

Web Resources