NCI-H2286Homo sapiens (Human)Cancer cell line

Also known as: NCIH2286, H-2286, H2286

🤖 AI SummaryBased on 7 publications

Quick Overview

Human cancer cell line with potential applications in lung cancer research.

Detailed Summary

The NCI-H2286 cell line is a human cancer cell line derived from non-small cell lung cancer (NSCLC). It is part of a large panel of cell lines used in cancer research, including the Cancer Cell Line Encyclopedia (CCLE) and other comprehensive datasets. This cell line has been characterized for its genetic and molecular profiles, including mutations and gene expression patterns. It is utilized in studies related to drug sensitivity, genomic alterations, and cancer biology. The cell line is also part of efforts to understand the genetic diversity and ancestry in cancer research, highlighting its importance in translational studies and precision medicine approaches.

Research Applications

Lung cancer researchGenomic and molecular profilingDrug sensitivity studiesCancer biology investigations

Key Characteristics

Part of the CCLE and other large cell line panelsCharacterized for mutations and gene expressionUsed in studies of cancer genetics and precision medicine

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1545
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	57
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-000912_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Lys291Ter (c.871A>T)	Unspecified	-	PubMed=19147553
MutationSimple	SMARCA4	p.Arg1135Gln (c.3404G>A)	Homozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

11,12

D18S51

13,17

D19S433

14,14.1

D21S11

27,33.2

D2S1338

19,25

D3S1358

D5S818

11,12

D7S820

10,11

D8S1179

FGA

Penta D

Penta E

TH01

6,9.3

TPOX

11,12

vWA

15,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Molecular and pathologic characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies.

Burr M.L., Sutherland K.D.

Clin. Cancer Res. 30:1846-1858(2024).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Web Resources

tcpaportal.org