NCI-H2291Homo sapiens (Human)Cancer cell line

Also known as: NCIH2291, H-2291, H2291

🤖 AI SummaryBased on 6 publications

Quick Overview

Human lung cancer cell line with known mutations and drug sensitivity profiles.

Detailed Summary

The NCI-H2291 cell line is a human lung cancer cell line derived from a pleural effusion. It is widely used in cancer research due to its well-characterized genetic profile and drug sensitivity patterns. This cell line has been extensively studied in the context of the Cancer Cell Line Encyclopedia (CCLE) and has been utilized in various studies to understand the molecular mechanisms of cancer and to develop targeted therapies. The cell line exhibits specific mutations that contribute to its oncogenic potential and has been shown to respond to certain chemotherapeutic agents. Its use in preclinical models has provided valuable insights into cancer biology and treatment strategies.

Research Applications

Cancer researchDrug sensitivity profilingMolecular mechanism studies

Key Characteristics

Well-characterized genetic profileDrug sensitivity patternsUsed in CCLE for predictive modeling

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1546
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age Category	Unknown
Sex	Male

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000718_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gly154Val (c.461G>T)	Homozygous	-	Unknown
MutationSimple	KRAS	p.Gly12Phe (c.34_35GG>TT) (c.34_35delinsTT)	Homozygous	-	Unknown, Unknown, PubMed=12068308

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

9,12

D18S51

D19S433

D21S11

30,30.2

D2S1338

17,20

D3S1358

14,16

D5S818

D7S820

9,11

D8S1179

12,14

FGA

23,24

Penta D

12,13

Penta E

7,10

TH01

9,9.3

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed