NCI-H2342Homo sapiens (Human)Cancer cell line

Also known as: NCIH2342, H-2342, H2342

🤖 AI SummaryBased on 6 publications

Quick Overview

Human cancer cell line for research on genetic mutations and drug sensitivity.

Detailed Summary

The NCI-H2342 cell line is a human cancer cell line derived from a tumor, though the specific tissue and disease origin remain unspecified. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been utilized in studies examining the relationship between genetic mutations and drug sensitivity. Research involving this cell line has contributed to understanding how specific mutations affect cancer progression and response to therapeutic agents. The cell line is also part of broader efforts to characterize the genomic and molecular profiles of cancer cells, aiding in the development of targeted therapies. While the exact tissue of origin is unknown, the cell line has been used in various studies to explore cancer biology and potential treatment strategies.

Research Applications

Genetic mutation analysisDrug sensitivity testingCancer biology research

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Used in studies on genetic mutations and drug responseContributes to understanding cancer progression and treatment

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1549
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	55
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000951_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr220Cys (c.659A>G)	Unspecified	-	PubMed=21173094

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

D18S51

D19S433

13,16

D21S11

31.2,32

D2S1338

19,26

D3S1358

D5S818

D7S820

D8S1179

14,15

FGA

Penta D

Penta E

TH01

9,9.3

TPOX

8,10

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Web Resources

tcpaportal.org