NCI-H660Homo sapiens (Human)Cancer cell line

Also known as: NCI660, NCIH660, H-660, H660, NCI_H600 (Prior to 2020.)

🤖 AI SummaryBased on 12 publications

Quick Overview

NCI-H660 is a prostate cancer cell line used in research for understanding cancer biology and drug development.

Detailed Summary

The NCI-H660 cell line is derived from a small cell carcinoma of the prostate and is widely used in cancer research. It is known for its role in studying the molecular mechanisms of prostate cancer, including the analysis of genetic alterations and their implications in tumor progression. This cell line has been utilized in various studies to investigate the effects of different treatments and to understand the genetic basis of cancer development. Researchers have used NCI-H660 to explore the relationship between specific gene mutations and cancer behavior, contributing to the development of targeted therapies. The cell line's characteristics make it a valuable tool for in vitro studies in the field of oncology.

Research Applications

Cancer biology researchDrug developmentGenetic mutation analysisTumor progression studies

Key Characteristics

Used for studying prostate cancer mechanismsUtilized in genetic and molecular studiesRelevant for understanding cancer progression

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1576
Species	Homo sapiens (Human)
Tissue Source	Cervical lymph node[UBERON:UBERON_0002429]

Donor Information

Age	63
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Prostate small cell carcinoma
Lineage	Prostate
Subtype	Prostate Small Cell Carcinoma
OncoTree Code	PRSCC

DepMap Information

Source Type	ATCC
Source ID	ACH-000177_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
Gene fusion	ERG	TMPRSS2-ERG	-	-	from parent cell line VCaP

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D18S51

15,16

D19S433

D21S11

28,31

D2S1338

18,24

D3S1358

14,18

D5S818

D7S820

8,10

D8S1179

9,10

FGA

23,24

Penta D

9,12

Penta E

TH01

7,9.3

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A novel approach for characterizing microsatellite instability in cancer cells.

Lu Y.-H., Soong T.D., Elemento O.

PLoS ONE 8:E63056-E63056(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Molecular characterization of TMPRSS2-ERG gene fusion in the NCI-H660 prostate cancer cell line: a new perspective for an old model.

Lee C., Chinnaiyan A.M., Rubin M.A.

Neoplasia 9:200-206(2007).

DOI PubMed PMC

Cell lines used in prostate cancer research: a compendium of old and new lines -- part 1.

Sobel R.E., Sadar M.D.

J. Urol. 173:342-359(2005).

DOI PubMed

Molecular characterization of human prostate carcinoma cell lines.";

Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.

Prostate 57:205-225(2003).

DOI PubMed

Widely used prostate carcinoma cell lines share common origins.";

van Bokhoven A., Varella-Garcia M., Korch C.T., Hessels D., Miller G.J.

Prostate 47:36-51(2001).

DOI PubMed

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Oncogene 19:4632-4639(2000).

DOI PubMed

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

Ihde D.C., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:210-217(1996).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Establishment and identification of small cell lung cancer cell lines having classic and variant features.

Moody T.W., Zweig M.H., Minna J.D.

Cancer Res. 45:2913-2923(1985).

PubMed

Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies.

Simmons A.M., Russell E., Nam M.H., Gazdar A.F.

J. Natl. Cancer Inst. 81:1223-1228(1989).

DOI PubMed

Neuromedin B is present in lung cancer cell lines.";

Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.

Cancer Res. 52:2732s-2736s(1992).

PubMed