NCI-H727Homo sapiens (Human)Cancer cell line
Also known as: NCIH727, H-727, H727
Quick Overview
Human lung cancer cell line with KRAS mutations and potential for drug sensitivity studies.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1584 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 65 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Lung carcinoid tumor |
|---|---|
| Lineage | Lung |
| Subtype | Lung Carcinoid |
| OncoTree Code | LUCA |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000775_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gln165_Ser166insTyrLysGln (c.496_497insACAAGCAGT) (c.492_493ins9) | Heterozygous | - | Unknown, Unknown, PubMed=20557307, PubMed=1311061 |
| MutationSimple | KRAS | p.Gly12Val (c.35G>T) | Heterozygous | Acquired | Unknown, Unknown |
| Gene fusion | PKD1L1 | TNS3-PKD1L1 | - | - | PubMed=25485619 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
Aldige C.R., Wistuba I.I., Minna J.D.
J. Cell. Biochem. 121:3986-3999(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Posner B.A., Minna J.D., Kim H.S., White M.A.
Cell 173:864-878.e29(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.
Schroth G.P., Beutler A.S., Banck M.S.
Cancer Genet. 208:374-381(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Reconstructing targetable pathways in lung cancer by integrating diverse omics data.
Cao X.-H., Nesvizhskii A.I., Chinnaiyan A.M.
Nat. Commun. 4:2617.1-2617.13(2013).
The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells.
Castano J.P., Oberg K.E., Giandomenico V.
PLoS ONE 7:E48411-E48411(2012).
Human neuroendocrine tumor cell lines as a three-dimensional model for the study of human neuroendocrine tumor therapy.
Wong C., Vosburgh E., Levine A.J., Cong L., Xu E.Y.
J. Vis. Exp. 66:e4218.1-e4218.7(2012).
The role of cell lines in the study of neuroendocrine tumors.";
Grozinsky-Glasberg S., Shimon I., Rubinfeld H.
Neuroendocrinology 96:173-187(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.
Cancer Sci. 101:1891-1896(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A gene-alteration profile of human lung cancer cell lines.";
Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
Hum. Mutat. 30:1199-1206(2009).
Mutations of the BRAF gene in human cancer.";
Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Nature 417:949-954(2002).
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.
Oncogene 19:4632-4639(2000).
NCI-Navy Medical Oncology Branch cell line data base.";
Carney D.N., Minna J.D., Mulshine J.L.
J. Cell. Biochem. Suppl. 24:32-91(1996).
Insulin-like growth factor expression in human cancer cell lines.";
Grimley C., Battey J., Mulshine J.L., Cuttitta F.
J. Biol. Chem. 271:11477-11483(1996).
Neuromedin B is present in lung cancer cell lines.";
Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.
Cancer Res. 52:2732s-2736s(1992).
p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.
Gazdar A.F.
Oncogene 7:171-180(1992).