NCI-H920Homo sapiens (Human)Cancer cell line

Also known as: H-920, H920

🤖 AI SummaryBased on 4 publications

Quick Overview

Human cancer cell line with potential for drug sensitivity studies.

Detailed Summary

The NCI-H920 cell line is a human-derived cancer cell line that has been extensively characterized in large-scale genomic and transcriptomic studies. It is part of a comprehensive dataset of 675 cancer cell lines, providing insights into gene expression, mutations, and fusion events. This cell line is notable for its utility in studying oncogenic fusions and drug response, particularly in the context of targeted therapies. Research has identified specific gene fusions and mutations that may influence its sensitivity to various therapeutic agents. The cell line's molecular profile supports its use in investigating the mechanisms of cancer progression and in developing personalized treatment strategies.

Research Applications

Oncogenic fusion detectionDrug sensitivity profilingGenomic and transcriptomic analysis

Key Characteristics

Extensive genomic characterizationPotential for targeted therapy researchInvolvement in large-scale cancer studies

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1599
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Additional Information	Established from a 75 packs per year smoker (ATCC=CRL-5850)
Age	43
Age Category	Adult
Sex	Male

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-002497_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.560-1G>T	Unspecified	Splice acceptor mutation	PubMed=33802339

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

11,13

D18S51

10,13

D19S433

D21S11

29,30

D2S1338

18,22,23

D3S1358

D5S818

D7S820

D8S1179

12,15

FGA

22,24

Penta D

Penta E

TH01

9.3

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Peripheral airway cell differentiation in human lung cancer cell lines.

Clark J.C., Whitsett J.A.

Cancer Res. 50:5481-5487(1990).

PubMed

Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.

Linnoila R.I.

Oncogene 7:743-749(1992).

PubMed

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.

Gazdar A.F.

Oncogene 7:171-180(1992).

PubMed

Web Resources

tcpaportal.org