NCI-N87Homo sapiens (Human)Cancer cell line
Also known as: NCIN87, H-87, H87, NCI-H87, N-87, N87, NCI N87, NU-N87 (Also in all the NCBI data records associated with the BioSample record.)
Quick Overview
Human gastric cancer cell line with ZAK isoform upregulation and potential for targeted therapy research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1603 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Gastric tubular adenocarcinoma |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Tubular Stomach Adenocarcinoma |
| OncoTree Code | TSTAD |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000427_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Gln (c.743G>A) | Unspecified | Somatic mutation acquired during proliferation | PubMed=20575032 |
| MutationSimple | ERBB3 | p.Thr757Lys (c.2270C>A) | Unspecified | - | from parent cell line NCI-N87 |
| Gene deletion | SMAD4 | - | Homozygous | - | from parent cell line BxPC-3 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
Aldige C.R., Wistuba I.I., Minna J.D.
J. Cell. Biochem. 121:3986-3999(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.
Kragh M., Horak I.D., Chung H.C., Rha S.Y.
Int. J. Cancer 143:151-159(2018).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
Strauss S.J., Pillay N., Flanagan A.M.
J. Pathol. 239:320-334(2016).
Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer.
Tebaldi M., Tedaldi G., Tesei A.
Oncotarget 7:18424-18439(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Firestein R., Zhang Z.-M.
Nat. Commun. 5:3830.1-3830.8(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer.
Noh S.H., Rha S.Y.
Genomics 93:52-61(2009).
Biology of colorectal and gastric cancer cell lines.";
Park J.-G., Gazdar A.F.
J. Cell. Biochem. Suppl. 24:131-141(1996).
NCI-Navy Medical Oncology Branch cell line data base.";
Carney D.N., Minna J.D., Mulshine J.L.
J. Cell. Biochem. Suppl. 24:32-91(1996).
NCI series of cell lines: an historical perspective.";
Gazdar A.F., Minna J.D.
J. Cell. Biochem. 63 Suppl. 24:1-11(1996).
Characteristics of cell lines established from human gastric carcinoma.
Bang Y.-J., Kim J.-P., Gazdar A.F.
Cancer Res. 50:2773-2780(1990).
Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.
Lee H.-D., Kim J.-P., Minna J.D., Gazdar A.F.
J. Natl. Cancer Inst. 83:938-943(1991).
Gastric tumor cell lines.";
Sekiguchi M., Suzuki T.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994).