NH-12Homo sapiens (Human)Cancer cell line

Also known as: Neuroblastoma-12, NH12

🤖 AI SummaryBased on 4 publications

Quick Overview

Human cell line with potential applications in cancer research.

Detailed Summary

The NH-12 cell line, identified by the ID CVCL_1605, is derived from Homo sapiens. However, specific details regarding its tissue origin, disease context, and cell type remain unspecified in the available data. This cell line has been utilized in research studies focusing on cancer genomics, particularly in the analysis of genetic alterations and their implications in tumorigenesis. The studies highlight the importance of understanding the molecular mechanisms underlying cancer development and progression, although specific applications related to NH-12 are not detailed in the provided information. Researchers have employed this cell line to investigate various aspects of cancer biology, including the identification of genetic mutations and their potential roles in cancer progression. Further research is needed to fully characterize the properties and applications of the NH-12 cell line in cancer studies.

Research Applications

Cancer genomicsGenetic alteration analysisCancer biology research

Key Characteristics

Human originPotential for cancer researchGenetic studies

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1605
Species	Homo sapiens (Human)
Tissue Source	Adrenal gland[UBERON:UBERON_0002369]

Donor Information

Age	1
Age Category	Pediatric
Sex	Male

Disease Information

Disease	Neuroblastoma
Lineage	Peripheral Nervous System
Subtype	Neuroblastoma
OncoTree Code	NBL

DepMap Information

Source Type	JCRB
Source ID	ACH-001603_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,12

D13S317

8,9

D16S539

D18S51

14,15

D21S11

29,31

D3S1358

D5S818

10,11

D7S820

11,13

D8S1179

10,15

FGA

23,26

Penta D

11,12

Penta E

19,20

TH01

9,10

TPOX

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Oncogenic mutations of ALK kinase in neuroblastoma.";

Hayashi Y., Mano H., Ogawa S.

Nature 455:971-974(2008).

DOI PubMed

Malignant rhabdoid tumor shows incomplete neural characteristics as revealed by expression of SNARE complex.

Yoshida S., Narita T., Taga T., Ohta S., Takeuchi Y.

J. Neurosci. Res. 69:642-652(2002).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed