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NUGC-2Homo sapiens (Human)Cancer cell line

Also known as: Nagoya University-Gastric Cancer-2, NU-GC-2, NUGC2, NuGC-2, MUGC-2

🤖 AI SummaryBased on 10 publications

Quick Overview

Human gastric cancer cell line with distinct genetic and phenotypic characteristics.

Detailed Summary

NUGC-2 is a human gastric cancer cell line established from metastatic paragastric lymph nodes. It exhibits unique morphological and genetic features, including a poorly differentiated adenocarcinoma histology with some signet-ring cell characteristics. The cell line shows distinct patterns of tyrosine phosphorylation and has been used in studies related to cancer cell signaling and drug sensitivity. NUGC-2 is part of a panel of gastric cancer cell lines that have been analyzed for their genomic and transcriptomic profiles, contributing to the understanding of gastric cancer biology and potential therapeutic targets.

Research Applications

Cancer signaling pathwaysDrug sensitivity testingGenomic and transcriptomic analysis

Key Characteristics

Poorly differentiated adenocarcinomaTyrosine phosphorylation patternsMetastatic origin

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1611
Species	Homo sapiens (Human)
Tissue Source	Paragastric lymph node[UBERON:UBERON_8480059]

Donor Information

Age	56
Age Category	Adult
Sex	Female

Disease Information

Disease	Gastric adenocarcinoma
Lineage	Esophagus/Stomach
Subtype	Stomach Adenocarcinoma
OncoTree Code	STAD

DepMap Information

Source Type	HSRRB
Source ID	ACH-000761_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gly245Ser (c.733G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=28445466
MutationSimple	KRAS	p.Thr58Ile (c.173C>T)	Heterozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,12

D13S317

8,11

D16S539

7

D18S51

21

D21S11

29

D3S1358

15,16

D5S818

10,12

D7S820

11

D8S1179

13

FGA

21

Penta D

12

Penta E

11

TH01

7

TPOX

11

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients.

Omata M.

APMIS 116:931-933(2008).

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Okanoue T., Inazawa J.

Cancer Sci. 96:100-110(2005).

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer xenografts in athymic nude mice.

Kondo S.

Carcinogenesis 6:549-553(1985).

Characteristics of three human gastric cancer cell lines, NU-GC-2, NU-GC-3 and NU-GC-4.

Imaizumi M., Ichihashi H., Kondo T., Takagi H.

Jpn. J. Surg. 18:438-446(1988).

Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.

Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.

Jpn. J. Cancer Res. 82:1428-1435(1991).