OAW28Homo sapiens (Human)Cancer cell line

Also known as: OAW 28, OAW-28, OWA28

🤖 AI SummaryBased on 12 publications

Quick Overview

Ovarian cancer cell line with potential for drug sensitivity studies.

Detailed Summary

OAW28 is a human ovarian cancer cell line derived from ascitic fluid. It exhibits epithelial characteristics, as confirmed by HMFG2 staining and ultrastructural features. The cell line shows variability in doubling times and clonogenicity in soft agar, with a reported doubling time of approximately 60 hours. OAW28 has been used in studies evaluating responses to platinum-based chemotherapeutic agents, indicating its utility in preclinical drug screening. Its karyotype is complex, with multiple structural and numerical chromosomal changes, and it displays heterogeneity in marker expression, including positive staining for epithelial markers and variable expression of vimentin and keratin. OAW28 is part of a panel of cell lines used to study ovarian cancer biology and therapeutic responses.

Research Applications

Drug sensitivity studiesPreclinical drug screeningOvarian cancer biology research

Key Characteristics

Epithelial originVariable doubling timeClonogenic potential in soft agarComplex karyotypeHeterogeneous marker expression
Generated on 6/17/2025

Basic Information

Database IDCVCL_1614
SpeciesHomo sapiens (Human)
Tissue SourceAscites[UBERON:UBERON_0007795]

Donor Information

Age75
Age CategoryAdult
SexFemale

Disease Information

DiseaseHigh grade ovarian serous adenocarcinoma
LineageOvary/Fallopian Tube
SubtypeHigh-Grade Serous Ovarian Cancer
OncoTree CodeHGSOC

DepMap Information

Source TypeECACC
Source IDACH-000116_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Pro152Argfs*18 (c.455delC)Heterozygous-from parent cell line OVK18

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11
D13S317
11
D16S539
13
D18S51
12,14
D19S433
13
D21S11
29
D2S1338
20,23
D3S1358
14,18
D5S818
12
D7S820
11
D8S1179
11,15
FGA
21,24
Penta D
9
Penta E
7
TH01
9
TPOX
8
vWA
17,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.

Velculescu V.E., Scharpf R.B.

Cell Rep. 25:2617-2633(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

Helleman J.

PLoS ONE 9:E103988-E103988(2014).

Evaluating cell lines as tumour models by comparison of genomic profiles.

Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.

Nat. Commun. 4:2126.1-2126.10(2013).

BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.

Mills G.B., Hennessy B.T.

Mol. Oncol. 7:567-579(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Characterisation of seven human ovarian tumour cell lines.";

Wilson A.P., Dent M.F., Pejovic T., Hubbold L., Radford H.

Br. J. Cancer 74:722-727(1996).

Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes.

Harrap K.R.

Br. J. Cancer 59:527-534(1989).

Web Resources