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OC 314Homo sapiens (Human)Cancer cell line

Also known as: OC314, OC-314

🤖 AI SummaryBased on 5 publications

Quick Overview

Human cancer cell line with unknown tissue and disease origin.

Detailed Summary

OC 314 is a human cancer cell line with unknown tissue and disease origin. The cell line is part of a collection of cancer cell lines used in research, but specific details about its characteristics, such as genetic mutations or molecular profiles, are not provided in the available data. It is important to note that the cell line's origin and specific properties are not well characterized, which may limit its utility in certain research applications. Further studies are needed to fully understand the biological and molecular features of OC 314.

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1616
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age	39
Age Category	Adult
Sex	Female

Disease Information

Disease	Ovarian serous adenocarcinoma
Lineage	Ovary/Fallopian Tube
Subtype	Serous Ovarian Cancer
OncoTree Code	SOC

DepMap Information

Source Type	ICLC
Source ID	ACH-000962_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273His (c.818G>A)	Homozygous	-	Unknown, PubMed=16264262
MutationSimple	RRAS	p.Pro26fs (c.74delC)	Heterozygous	-	Unknown
MutationSimple	B2M	p.Leu15Phefs*41 (c.43_44delCT)	Heterozygous	Total loss of HLA class 1 expression	from parent cell line LoVo

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10

D13S317

8,9

D16S539

10,11,12

D5S818

10,12

D7S820

11

TH01

6,8

TPOX

8

vWA

15,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.

Edwards P.A.W., Caldas C.

Carcinogenesis 26:923-930(2005).

Establishment and characterization of three new cell lines derived from the ascites of human ovarian carcinomas.

Viale M., Foglia G., Ragni N.

Gynecol. Oncol. 62:82-88(1996).