OCI-AML-5Homo sapiens (Human)Cancer cell line

Also known as: Ontario Cancer Institute-Acute Myeloid Leukemia-5, OCIAML5, OCI AML5, OCI/AML5, OCI-AML5, OCI/AML-5

🤖 AI SummaryBased on 9 publications

Quick Overview

OCI-AML-5 is a human acute myeloid leukemia cell line derived from peripheral blood, commonly used in research on myeloprolifer...

Detailed Summary

OCI-AML-5 is a human acute myeloid leukemia cell line established from peripheral blood. It is widely utilized in research related to myeloproliferative disorders and JAK2 mutations, particularly in studies examining the JAK2 V617F mutation. This cell line has been identified as a valuable tool for investigating the role of JAK2 mutations in leukemogenesis and their implications in disease progression. Additionally, OCI-AML-5 is used in studies involving thrombopoietin (TPO) and its effects on cell growth and differentiation. The cell line's characteristics make it suitable for studying the molecular mechanisms underlying AML and for evaluating therapeutic strategies targeting JAK2 pathways.

Research Applications

Myeloproliferative disordersJAK2 mutationsThrombopoietin (TPO) studiesLeukemogenesisTherapeutic strategies targeting JAK2 pathways

Key Characteristics

JAK2 V617F mutationPeripheral blood originUsed in JAK2-related research
Generated on 6/17/2025

Basic Information

Database IDCVCL_1620
SpeciesHomo sapiens (Human)
Tissue SourcePeripheral blood[UBERON:UBERON_0000178]

Donor Information

Age77
Age CategoryAdult
SexMale

Disease Information

DiseaseAcute myeloid leukemia
LineageMyeloid
SubtypeAcute Myeloid Leukemia
OncoTree CodeAML

DepMap Information

Source TypeDSMZ
Source IDACH-000065_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleBCORL1p.Lys1085Argfs*7 (c.3252delT)Unspecified-PubMed=21989985

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
10,11
D13S317
11,14
D16S539
11,13
D18S51
15,17
D19S433
12,16
D21S11
28,32.2
D2S1338
19,22
D3S1358
18
D5S818
12,13
D7S820
11,12
D8S1179
13,14
FGA
19,24
Penta D
9
Penta E
13,18
TH01
7,9.3
TPOX
8,11
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia.

Esteller M.

Oncogene 35:3079-3082(2016).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia.

Vogelstein B., Kinzler K.W., Papadopoulos N., Malek S.N.

Blood 118:5914-5917(2011).

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.

Drexler H.G., Zaborski M., Quentmeier H.

Leukemia 11:541-551(1997).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).