OE19Homo sapiens (Human)Cancer cell line
Also known as: OEC19, JROECL19, JROECL 19, OE-19
Quick Overview
Human esophageal adenocarcinoma cell line with ERBB2 amplification and high polysomy.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1622 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Esophagus[UBERON:UBERON_0001043] |
Donor Information
| Age | 72 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Adenocarcinoma of the esophagus |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Esophageal Squamous Cell Carcinoma |
| OncoTree Code | ESCC |
DepMap Information
| Source Type | HPACC |
|---|---|
| Source ID | ACH-000679_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Asn310Lysfs*27 (c.929dup) (c.929_930ins1) | Heterozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Nat. Commun. 10:3574.1-3574.11(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Hypermethylation of MAPK13 promoter in oesophageal squamous cell carcinoma is associated with loss of p38delta MAPK expression.
O'Callaghan C., Fanning L.J., Barry O.P.
Cancers (Basel) 7:2124-2133(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Esophageal carcinoma cell line with high EGFR polysomy is responsive to gefitinib.
Gros S.J.
Langenbecks Arch. Surg. 399:879-888(2014).
Growth, clonability, and radiation resistance of esophageal carcinoma-derived stem-like cells.
Pan J.-J.
Asian Pac. J. Cancer Prev. 14:4891-4896(2013).
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Dis. Esophagus 28:90-96(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
J. Natl. Cancer Inst. 102:271-274(2010).
Comparative genomic hybridization of esophageal adenocarcinoma and squamous cell carcinoma cell lines.
Fitzgerald R.C.
Dis. Esophagus 19:10-14(2006).
ERBB2 amplifications in esophageal adenocarcinoma.";
Maddaus M.A., Ferrin L.J.
Ann. Thorac. Surg. 78:1790-1800(2004).