ONS-76Homo sapiens (Human)Cancer cell line

Also known as: Osaka Neurological Surgery-76, ONS76

🤖 AI SummaryBased on 9 publications

Quick Overview

Human medulloblastoma cell line for cancer research and drug development.

Detailed Summary

The ONS-76 cell line is a human medulloblastoma cell line derived from a pediatric patient. It is used in research to study the molecular mechanisms of medulloblastoma, a common malignant brain tumor in children. ONS-76 exhibits characteristics of neuronal and glial differentiation, as indicated by the expression of markers such as NSE, synaptophysin, and NFP. The cell line has been utilized in studies investigating the role of HLA class II antigens and their induction by interferon-gamma. Additionally, ONS-76 has been analyzed for its proliferative potential, migratory behavior, and tumorigenicity in vivo. These properties make it a valuable model for understanding medulloblastoma biology and developing targeted therapies.

Research Applications

Cancer researchDrug developmentMolecular mechanism studiesImmunotherapy research

Key Characteristics

Expresses neuronal and glial markersInducible HLA class II antigensProliferative and migratory potentialTumorigenic in vivo

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1624
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	2
Age Category	Pediatric
Sex	Female
Subtype Features	MYC_No

Disease Information

Disease	Medulloblastoma
Lineage	CNS/Brain
Subtype	Medulloblastoma
OncoTree Code	MBL

DepMap Information

Source Type	HSRRB
Source ID	ACH-000776_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationNone reported	TP53	-	-	-	PubMed=19787792
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	NRAS	p.Gln61Arg (c.182A>G)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

8,13

D16S539

9,10

D18S51

14,21

D19S433

14,15.2

D21S11

29,30.3

D2S1338

17,19

D3S1358

D5S818

9,10

D7S820

11,12

D8S1179

FGA

Penta D

12,13

Penta E

15,16

TH01

TPOX

vWA

14,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Biological characterization of the UW402, UW473, ONS-76 and DAOY pediatric medulloblastoma cell lines.

de Oliveira Menezes C.C.B., Palma P.V.B., Fontes A.M.

Cytotechnology 71:893-903(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.

Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.

Data Brief 9:696-698(2016).

DOI PubMed PMC

In vitro models of medulloblastoma: choosing the right tool for the job.

Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.

J. Biotechnol. 236:10-25(2016).

DOI PubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

In vitro stemness characterization of radio-resistant clones isolated from a medulloblastoma cell line ONS-76.

Zenkoh J., Taniguchi H., Tsuboi K.

J. Radiat. Res. 54:61-69(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Establishment and biological characterization of human medulloblastoma cell lines.

Park K.C., Mabuchi E., Yamamoto K., Hayakawa T., Mogami H.

No To Shinkei 41:695-702(1989).

PubMed

Expression of major histocompatibility complex on human medulloblastoma cells with neuronal differentiation.

Mabuchi E., Moriuchi S., Mogami H.

Cancer Res. 49:5380-5384(1989).

PubMed

In vitro chemosensitivity test with several antitumor agents against eight malignant brain tumor cell-lines.

Hayakawa T., Mogami H.

Gan To Kagaku Ryoho 18:233-238(1991).

PubMed

Human glioma cell lines.";

Nister M., Westermark B.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York; USA (1994).

DOI

Biological characterization of human medulloblastoma (ONS-76 and ONS-81) cell lines.

Miyao Y., Park K.C., Hayakawa T.

(In book chapter) Biological aspects of brain tumors. Proceedings of the 8th Nikko brain tumor conference, Karatsu (Saga) 1990; Tabuchi K. (eds.); pp.442-446; Springer; Tokyo; Japan (1991).

DOI