OS-RC-2Homo sapiens (Human)Cancer cell line

Also known as: RC-2, OSRC2

🤖 AI SummaryBased on 7 publications

Quick Overview

Renal cell carcinoma cell line with clear cell morphology and tumorigenic potential.

Detailed Summary

OS-RC-2 is a human renal cell carcinoma cell line established from a clear cell tumor. It exhibits epithelial morphology and lacks contact inhibition, demonstrating tumorigenicity in nude mice. The cell line maintains stable growth characteristics over multiple passages and has been used in studies investigating renal cancer biology, including genomic and molecular analyses. OS-RC-2 is notable for its ability to form tumors in vivo, making it a valuable model for studying renal carcinoma progression and therapeutic responses. Its chromosomal abnormalities, including a hypodiploid karyotype with translocations, contribute to its characterization as a renal cancer model.

Research Applications

Cancer biology researchGenomic and molecular analysisTumor progression studiesTherapeutic response modeling

Key Characteristics

Epithelial morphologyTumorigenic in nude miceStable growth over passagesChromosomal abnormalities

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1626
Species	Homo sapiens (Human)
Tissue Source	Kidney[UBERON:UBERON_0002113]

Donor Information

Age	52
Age Category	Adult
Sex	Male

Disease Information

Disease	Clear cell renal carcinoma
Lineage	Kidney
Subtype	Renal Clear Cell Carcinoma
OncoTree Code	CCRCC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000159_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationNone reported	TP53	-	-	-	PubMed=19787792
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	PTEN	p.Cys211Serfs (c.631_634+12del16)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

12,13

D13S317

8,12

D16S539

D18S51

D19S433

13,14

D21S11

31.2

D2S1338

D3S1358

D5S818

11,12

D7S820

10,11

D8S1179

FGA

TH01

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.

Hsieh J.J.-D., Hakimi A.A.

Nat. Commun. 8:15165.1-15165.10(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with interferon-alpha in renal cell carcinoma cell lines.

Nakatani T.

Urol. Int. 73:348-353(2004).

DOI PubMed

Effects of tumor necrosis factor alpha in renal cell carcinoma.";

Nakatani T.

Oncol. Rep. 10:1947-1955(2003).

DOI PubMed

Human renal cell carcinoma: establishment and characterization of a new cell line (OS-RC-2).

Kinouchi T., Kotake T., Mori Y., Abe T.

In Vitro Cell. Dev. Biol. 21:195-199(1985).

DOI PubMed