P12-IchikawaHomo sapiens (Human)Cancer cell line

Also known as: P12, P-12, P12-ICH, P12/ICh, P12/ICH, P12ICHIKAWA, P12ichikawa, P12:ichikawa, p12/Ichikawa, P12/Ichikawa, P12/ICHIKAWA, P12-ICHIKAWA

🤖 AI SummaryBased on 13 publications

Quick Overview

Human T-cell acute lymphoblastic leukemia cell line with known genetic alterations

Detailed Summary

The P12-Ichikawa cell line is a human T-cell acute lymphoblastic leukemia (T-ALL) cell line derived from a patient with T-cell leukemia. It is characterized by specific genetic alterations, including mutations in the p16INK4A gene, which is a critical tumor suppressor involved in cell cycle regulation. This cell line is frequently used in research to study the molecular mechanisms of T-ALL, particularly focusing on the role of cell cycle regulators and their implications in leukemogenesis. The P12-Ichikawa cell line has been utilized in studies investigating the inactivation of tumor suppressor genes and the development of targeted therapies for T-ALL. Its genetic profile makes it a valuable model for understanding the pathogenesis of T-cell malignancies and for testing potential therapeutic strategies.

Research Applications

Molecular mechanisms of T-cell acute lymphoblastic leukemiaGenetic alterations in T-ALLTumor suppressor gene inactivationDevelopment of targeted therapies for T-ALL

Key Characteristics

Mutations in p16INK4A geneT-cell lineageUsed for studying cell cycle regulation in leukemiaModel for T-cell malignancies

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1630
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	7
Age Category	Pediatric
Sex	Male
Subtype Features	LMO2

Disease Information

Disease	Precursor T-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	T-Lymphoblastic Leukemia/Lymphoma
OncoTree Code	TLL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000372_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Pro (c.743G>C)	Heterozygous	-	Unknown, PubMed=22675565, PubMed=10071127
MutationSimple	TP53	p.Glu11Gln (c.31G>C)	Unspecified	-	PubMed=32321971
MutationSimple	NRAS	p.Gly12Asp (c.35G>A)	Unspecified	Somatic	Wistar
MutationSimple	NOTCH1	p.Ala1720_Val1721ins14 (c.5161_5162ins42)	Heterozygous	-	PubMed=15472075
MutationSimple	FBXW7	p.Arg505Cys (c.1513C>T)	Heterozygous	-	from parent cell line Jurkat
MutationSimple	APC	p.Gly253Ser (c.757G>A)	Heterozygous	-	Unknown, PubMed=22675565

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,13

D13S317

10,11

D16S539

9,10

D18S51

14,17

D19S433

D21S11

D2S1338

17,19

D3S1358

16,17

D5S818

12,13

D7S820

11,12

D8S1179

12,16

FGA

Penta D

10,13.4

Penta E

10,19

TH01

6,9

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

High accuracy mutation detection in leukemia on a selected panel of cancer genes.

Cools J., Aerts S.

PLoS ONE 7:E38463-E38463(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Langerak A.W.

Leukemia 21:230-237(2007).

DOI PubMed

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.

Science 306:269-271(2004).

DOI PubMed

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

DOI PubMed

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

DOI PubMed

Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.

Sekiya T., Hayashi Y.

Leuk. Res. 23:115-126(1999).

DOI PubMed

Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.

Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.

Leuk. Res. 23:19-27(1999).

DOI PubMed

p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.

Einhorn S.

Eur. J. Haematol. 56:313-318(1996).

DOI PubMed

Interferon system defects in malignant T-cells.";

Xu B., Einhorn S.

Leukemia 8:425-434(1994).

PubMed

Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.

Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.

Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).

DOI PubMed PMC

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI