P30/OHKHomo sapiens (Human)Cancer cell line

Also known as: P30/0HK, P30-OHKUBO, P30/OHKUBO, P30/Ohkubo, P30OHK, P30 OHK, P30_OHK, P30-OHK

🤖 AI SummaryBased on 9 publications

P30/OHKUBO

Quick Overview

Human B-cell precursor acute lymphoblastic leukemia cell line with specific genetic alterations.

Detailed Summary

P30/OHKUBO is a human B-cell precursor acute lymphoblastic leukemia (B-ALL) cell line established from a patient with acute lymphoblastic leukemia. It is characterized by specific genetic alterations, including deletions in the IKZF1 gene, which is associated with poor prognosis in B-ALL. The cell line has been used in studies to investigate the molecular mechanisms underlying leukemogenesis and drug resistance. Research on P30/OHKUBO has contributed to understanding the role of genetic alterations in the development and progression of B-ALL, particularly in relation to the IKZF1 deletion and its implications for treatment outcomes.

Research Applications

Genetic analysis of B-ALLInvestigation of IKZF1 deletionsStudy of leukemogenesis mechanismsDrug resistance research

Key Characteristics

IKZF1 deletionB-cell precursor originAcute lymphoblastic leukemia

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1631
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	11
Age Category	Pediatric
Sex	Female
Subtype Features	MEF2D

Disease Information

Disease	Precursor B-cell acute lymphoblastic leukemia
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma
OncoTree Code	BLL

DepMap Information

Source Type	RIKEN
Source ID	ACH-002059_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	NR3C1	p.Cys643Arg (c.1927T>C) (p.Cys644Arg, c.1930T>C)	Heterozygous	-	PubMed=35124168
Gene fusion	MEF2D	MEF2D-HNRNPUL1	-	-	PubMed=35354797

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

9,11

D13S317

9,10

D16S539

D18S51

12,13,14,16,17

D19S433

12,13

D21S11

30.2,32.2

D2S1338

D3S1358

D5S818

11,12

D7S820

10,11

D8S1179

10,12

FGA

Penta D

9,11

Penta E

12,18

TH01

8,9

TPOX

10,11

vWA

14,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOI PubMed PMC

Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.

Minegishi M., Iwamoto S., Sugita K., Inukai T.

J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).

DOI PubMed

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.

Sugita K., Hosoi H.

Int. J. Hematol. 108:312-318(2018).

DOI PubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

DOI PubMed

Establishment and characterization of human B cell precursor-leukemia cell lines.

Matsuo Y., Drexler H.G.

Leuk. Res. 22:567-579(1998).

DOI PubMed

Frameshift mutations of the hMSH6 gene in human leukemia cell lines.

Hirai H.

Jpn. J. Cancer Res. 89:33-39(1998).

DOI PubMed PMC

A novel pre-T cell line derived from acute lymphoblastic leukemia.";

Shimoyama M., Taniwaki M., Abe T.

Gann 73:600-605(1982).

PubMed

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI