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P31/FUJHomo sapiens (Human)Cancer cell line

Also known as: P31/Fujioka, P-31:FUJ, P31FUJ, P31 FUJ, P31-FUJ, P31-FUF, P31/FUF

🤖 AI SummaryBased on 10 publications

Quick Overview

Human cell line with potential role in leukemia research.

Detailed Summary

The P31/FUJ cell line is a human cell line derived from leukemia, with specific mutations in the cohesin complex and potential implications in myeloid malignancies. Research indicates that this cell line may be used to study the role of cohesin mutations in leukemogenesis and drug sensitivity. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for genetic and molecular characteristics relevant to cancer research.

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1632
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	7
Age Category	Pediatric
Sex	Male
Race	asian

Disease Information

Disease	Acute myeloid leukemia
Lineage	Myeloid
Subtype	Acute Myeloid Leukemia
OncoTree Code	AML

DepMap Information

Source Type	HSRRB
Source ID	ACH-000770_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr236Cys (c.707A>G)	Heterozygous	-	Unknown, Unknown
MutationSimple	TP53	p.Arg196Ter (c.586C>T)	Unspecified	-	PubMed=25275298
MutationSimple	RAD21	p.His208Arg (c.623A>G)	Heterozygous	-	Unknown, PubMed=23955599
MutationSimple	PTEN	p.Glu7Ter (c.19G>T)	Heterozygous	-	Unknown, Unknown
MutationSimple	NRAS	p.Gly12Cys (c.34G>T)	Heterozygous	In 3% of the reads	PubMed=34940123
MutationSimple	KMT2A	p.Arg158fs*13 (c.472_473insTTCC)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

13,14

D13S317

9,12,13

D16S539

9,10

D5S818

11

D7S820

10

TH01

9

TPOX

7,11

vWA

19,21

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.

Haferlach T., Shirahige K., Miyano S., Ogawa S.

Nat. Genet. 45:1232-1237(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

Tsuchida M., Sugita K., Ida K., Hayashi Y.

Blood 103:1085-1088(2004).

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia.

Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.

Leuk. Res. 21:697-701(1997).

A novel monocytoid cultured cell line, P31/Fujioka, derived from acute monoblastic leukemia.

Hirose M., Minato K., Tobinai K., Shimoyama M., Watanabe S., Abe T.

Gann 73:735-741(1982).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).