Panc 02.03Homo sapiens (Human)Cancer cell line

Also known as: Panc0203, PANC0203, PANC203, Panc203, PANC 203, Panc2_03, Panc2.03, Panc 2.03, Panc02.03, Panc_02_03, PANC-02-03

🤖 AI SummaryBased on 9 publications

Quick Overview

Pancreatic cancer cell line with known chromosomal abnormalities and metabolic subtypes.

Detailed Summary

Panc 02.03 is a pancreatic cancer cell line derived from human tissue, characterized by significant chromosomal abnormalities and metabolic heterogeneity. It has been used in studies to identify distinct metabolic subtypes, including glycolytic and lipogenic profiles, which correlate with different therapeutic responses. The cell line exhibits complex chromosomal rearrangements, particularly in regions such as 18q, and has been utilized in research to understand the molecular mechanisms underlying pancreatic cancer progression and drug sensitivity. Its metabolic characteristics make it a valuable model for studying the impact of metabolic inhibitors on cancer cell growth.

Research Applications

Chromosomal abnormality analysisMetabolic subtype identificationDrug sensitivity profilingGene fusion detection

Key Characteristics

Complex chromosomal rearrangementsMetabolic heterogeneityKnown 18q abnormalitiesUsed in metabolic inhibitor studies
Generated on 6/17/2025

Basic Information

Database IDCVCL_1633
SpeciesHomo sapiens (Human)
Tissue SourcePancreas[UBERON:UBERON_0001264]

Donor Information

Age70
Age CategoryAdult
SexFemale
Racecaucasian

Disease Information

DiseasePancreatic adenocarcinoma
LineagePancreas
SubtypePancreatic Adenocarcinoma
OncoTree CodePAAD

DepMap Information

Source TypeATCC
Source IDACH-000042_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Arg248Gln (c.743G>A)UnspecifiedSomatic mutation acquired during proliferationPubMed=20575032
MutationSimpleKRASp.Gly12Asp (c.35G>A)Unspecified-PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11,12
D13S317
12
D16S539
11
D18S51
14
D19S433
13,16
D21S11
28,31
D2S1338
19,20
D3S1358
14
D5S818
12,13
D7S820
9,10
D8S1179
11,12
FGA
20,21
Penta D
9
Penta E
5,7
TH01
6
TPOX
9,12
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling.

Biankin A.V., Wu J.-M., Daly R.J.

Mol. Cell. Proteomics 15:2671-2685(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Manning G., Settleman J., Hatzivassiliou G., Evangelista M.

Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.

Linnartz R., Zubel A., Slamon D.J., Finn R.S.

Br. J. Cancer 111:1788-1801(2014).

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Rottapel R., Neel B.G., Moffat J.

Cancer Discov. 2:172-189(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells.

Mendell J.T.

Cancer Biol. Ther. 8:2013-2024(2009).

Molecular cytogenetic characterization of pancreas cancer cell lines reveals high complexity chromosomal alterations.

Ried T., Schrock E., Perlman E.J., Jaffee E.M.

Cytogenet. Genome Res. 118:148-156(2007).

Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.

Thomas M., Greten T.F., Hruban R.H., Yeo C.J., Griffin C.A.

Cancer J. Sci. Am. 4:194-203(1998).