Panc 05.04Homo sapiens (Human)Cancer cell line

Also known as: PL18, PL-18, Pa18C, Panc0504, PANC0504, Panc5.04, Panc 5.04, Panc05.04, Panc_05_04, Panc-05.04

🤖 AI SummaryBased on 7 publications

Quick Overview

Pancreatic cancer cell line with known genetic mutations and drug sensitivity profiles.

Detailed Summary

Panc 05.04 is a human pancreatic cancer cell line derived from a pancreatic ductal adenocarcinoma. It is characterized by specific genetic mutations and has been used in studies to evaluate chemosensitivity to various anticancer drugs. Research has shown that its response to therapies can be influenced by its genetic profile, including mutations in genes such as DPC4/SMAD4 and P16/CDKN2A. This cell line is valuable for studying the relationship between genetic alterations and drug response in pancreatic cancer.

Research Applications

Chemosensitivity testingGenetic mutation analysisDrug response profiling

Key Characteristics

Mutations in DPC4/SMAD4Mutations in P16/CDKN2AVariable response to chemotherapeutic agents
Generated on 6/17/2025

Basic Information

Database IDCVCL_1637
SpeciesHomo sapiens (Human)
Tissue SourcePancreas[UBERON:UBERON_0001264]

Donor Information

Age77
Age CategoryAdult
SexFemale
Racecaucasian

Disease Information

DiseasePancreatic ductal adenocarcinoma
LineagePancreas
SubtypePancreatic Adenocarcinoma
OncoTree CodePAAD

DepMap Information

Source TypeATCC
Source IDACH-000093_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleKRASp.Gly12Asp (c.35G>A)Unspecified-PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12,13
D13S317
10,12
D16S539
9,11
D18S51
14
D19S433
13,15
D21S11
28,33.2
D2S1338
17
D3S1358
14,16
D5S818
12,13
D7S820
9,12
D8S1179
11,13
FGA
19,23
Penta D
7,9
Penta E
5,18
TH01
6,9.3
TPOX
8,9
vWA
15,20
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling.

Biankin A.V., Wu J.-M., Daly R.J.

Mol. Cell. Proteomics 15:2671-2685(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Manning G., Settleman J., Hatzivassiliou G., Evangelista M.

Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.

Linnartz R., Zubel A., Slamon D.J., Finn R.S.

Br. J. Cancer 111:1788-1801(2014).

Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.

Iacobuzio-Donahue C.A., Eshleman J.R.

Clin. Cancer Res. 18:6519-6530(2012).

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Rottapel R., Neel B.G., Moffat J.

Cancer Discov. 2:172-189(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.

Thomas M., Greten T.F., Hruban R.H., Yeo C.J., Griffin C.A.

Cancer J. Sci. Am. 4:194-203(1998).