PFSK-1Homo sapiens (Human)Cancer cell line

Also known as: PFSK, PFSK1, PFSk-1

🤖 AI SummaryBased on 4 publications

Quick Overview

PFSK-1 is a human cell line used in cancer research, derived from a glioblastoma multiforme tumor.

Detailed Summary

PFSK-1 is a human cell line established from a glioblastoma multiforme tumor, a highly aggressive form of brain cancer. This cell line is utilized in research to study the molecular mechanisms underlying glioblastoma progression and to evaluate potential therapeutic strategies. The cell line has been characterized in various studies, including those focusing on DNA methylation patterns and chromosomal abnormalities. It is part of a collection of cell lines used to investigate the genetic and epigenetic changes associated with cancer development and progression. PFSK-1 provides a valuable model for understanding the complexities of glioblastoma and for testing novel treatments.

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1642
Species	Homo sapiens (Human)
Tissue Source	Brain, right frontal lobe[UBERON:UBERON_0002810]

Donor Information

Age	1
Age Category	Pediatric
Sex	Male

Disease Information

Disease	Primitive neuroectodermal tumor
Lineage	CNS/Brain
Subtype	Primitive Neuroectodermal Tumor
OncoTree Code	PNET

DepMap Information

Source Type	ATCC
Source ID	ACH-001711_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys275Gly (c.823T>G)	Homozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

12,14

D16S539

D18S51

D19S433

13.2,14

D21S11

28,32.2

D2S1338

17,20

D3S1358

15,16,18

D5S818

11,12

D7S820

D8S1179

13,14

FGA

20,22

Penta D

9,12

Penta E

12,17

TH01

9,9.3

TPOX

8,9

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Dynamic DNA methylation across diverse human cell lines and tissues.

Crawford G.E., Absher D.M., Wold B.J., Myers R.M.

Genome Res. 23:555-567(2013).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Establishment and characterization of a human primitive neuroectodermal tumor cell line from the cerebral hemisphere.

Fults D.W., Pedone C.A., Morse H.G., Rose J.W., McKay R.D.G.

J. Neuropathol. Exp. Neurol. 51:272-280(1992).

DOI PubMed

Human glioma cell lines.";

Nister M., Westermark B.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York; USA (1994).

DOI

Web Resources

genome.ucsc.edu