RCC10RGBHomo sapiens (Human)Cancer cell line

Also known as: Hpt.10, RGB, 10RGB, RCC10 RGB, RCC-10RGB

🤖 AI SummaryBased on 9 publications

Quick Overview

RCC10RGB is a human renal cell carcinoma cell line used in cancer research.

Detailed Summary

RCC10RGB is a human renal cell carcinoma (RCC) cell line that has been utilized in various studies related to cancer biology and drug sensitivity. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its genetic and molecular characteristics. Research involving RCC10RGB has focused on understanding the role of thymidine phosphorylase (TP) in the response to chemotherapeutic agents such as 5-fluorouracil (5-FU) and 5'-deoxy-5-fluorouridine (5'-DFUR). Studies have shown that the expression of TP can influence the sensitivity of RCC cell lines to these drugs, with RCC10RGB demonstrating specific patterns of TP expression and response. Additionally, RCC10RGB has been used in investigations into the genomic and transcriptomic profiles of RCC, contributing to the understanding of molecular mechanisms underlying this type of cancer. The cell line is also part of efforts to develop predictive models for anticancer drug sensitivity and has been included in studies examining the relationship between genetic mutations and therapeutic outcomes.

Research Applications

Cancer biology researchDrug sensitivity profilingGenomic and transcriptomic analysisThymidine phosphorylase (TP) expression studiesPredictive modeling of anticancer drug response

Key Characteristics

Expresses thymidine phosphorylase (TP)Sensitivity to 5-fluorouracil (5-FU) and 5'-deoxy-5-fluorouridine (5'-DFUR)Part of the Cancer Cell Line Encyclopedia (CCLE)Used in studies of renal cell carcinoma (RCC) molecular mechanisms

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1647
Species	Homo sapiens (Human)
Tissue Source	Kidney[UBERON:UBERON_0002113]

Donor Information

Age Category	Unknown
Sex	Male
Race	asian

Disease Information

Disease	Renal cell carcinoma
Lineage	Kidney
Subtype	Renal Cell Carcinoma
OncoTree Code	RCC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000189_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

11,12

D16S539

12,13

D18S51

D21S11

29,30

D5S818

10,12

D7S820

12,13

D8S1179

12,16

FGA

24,25

TH01

6,9

TPOX

vWA

14,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.

Hsieh J.J.-D., Hakimi A.A.

Nat. Commun. 8:15165.1-15165.10(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with interferon-alpha in renal cell carcinoma cell lines.

Nakatani T.

Urol. Int. 73:348-353(2004).

DOI PubMed

Effects of tumor necrosis factor alpha in renal cell carcinoma.";

Nakatani T.

Oncol. Rep. 10:1947-1955(2003).

DOI PubMed

Short tandem repeat profiling provides an international reference standard for human cell lines.

Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.

Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).

DOI PubMed PMC

Expression of the SART1 tumor rejection antigen in renal cell carcinoma.

Yoshizumi O., Itoh K.

Urol. Res. 28:178-184(2000).

DOI PubMed