RERF-LC-Ad1Homo sapiens (Human)Cancer cell line
Also known as: Radiation Effects Research Foundation-Lung Cancer-Adenocarcinoma 1, RERFLCAd1, RERFLCAD1, RERF-LC-AD1
🤖 AI SummaryBased on 3 publications
Quick Overview
Human lung cancer cell line with EGFR mutations for cancer research.
Detailed Summary
RERF-LC-Ad1 is a human lung cancer cell line derived from Japanese patients, characterized by specific EGFR mutations. It is used in studies focusing on the genetic heterogeneity of EGFR in non-small cell lung cancer (NSCLC). The cell line has been screened for mutations in exons 18, 19, and 21 of the EGFR gene, revealing mutations such as L747-E749del, A750P, and others. This cell line is valuable for understanding the molecular mechanisms of lung cancer and for developing targeted therapies. Research on RERF-LC-Ad1 has contributed to the identification of subpopulations within cell lines that harbor distinct EGFR mutations, highlighting the complexity of cancer genetics. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and is used in pharmacological studies to evaluate drug sensitivity and resistance.
Research Applications
EGFR mutation analysis in lung cancerCancer genetics and molecular mechanismsDrug sensitivity and resistance studies
Key Characteristics
EGFR mutations in exons 18, 19, and 21Subpopulation with distinct EGFR mutationsPart of the Cancer Cell Line Encyclopedia (CCLE)
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1651 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 70 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Lung adenocarcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Lung Adenocarcinoma |
| OncoTree Code | LUAD |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-000791_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Pro278Phe (c.832_833CC>TT) | Homozygous | - | from parent cell line WM983B |
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
| MutationSimple | KRAS | p.Gly12Ala (c.35G>C) | Unspecified | - | PubMed=21173094 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12,13
D13S317
13
D16S539
9,12
D5S818
12
D7S820
11,12
TH01
6,9
TPOX
8,11
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Nat. Commun. 10:3574.1-3574.11(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.
Cancer Res. 65:7276-7282(2005).