RERF-LC-Ad2Homo sapiens (Human)Cancer cell line
Also known as: Radiation Effects Research Foundation-Lung Cancer-Adenocarcinoma 2, RERFLCAd2, RERFLCAD2, RERF-LC-AD2
🤖 AI SummaryBased on 4 publications
Quick Overview
Human lung cancer cell line with EGFR mutations and genetic heterogeneity.
Detailed Summary
RERF-LC-Ad2 is a human lung cancer cell line derived from Japanese patients, characterized by the presence of EGFR mutations and genetic heterogeneity. This cell line is part of a study that identified subpopulations within the cell line that harbor specific EGFR mutations, highlighting the complexity of tumor genetics. The cell line has been used in research to understand the variability in response to targeted therapies like gefitinib, which is influenced by the presence of these mutations. The genetic diversity observed in RERF-LC-Ad2 underscores the importance of considering tumor heterogeneity in cancer treatment strategies.
Research Applications
EGFR mutation analysisGenetic heterogeneity studiesResponse to gefitinibLung cancer research
Key Characteristics
Presence of EGFR mutationsGenetic heterogeneitySubpopulations with specific mutations
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1652 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Lung adenocarcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Lung Adenocarcinoma |
| OncoTree Code | LUAD |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-000774_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Ala159Val (c.476C>T) | Homozygous | - | Unknown |
| MutationSimple | KRAS | p.Gly12Val (c.35G>T) | Heterozygous | Acquired | Unknown, Unknown |
| MutationSimple | EGFR | p.Leu747_Ala750delinsPro (c.2239_2248delinsC) (c.2239_2248TTAAGAGAAG>C) | Unspecified | - | PubMed=16105816 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
8,12
D16S539
11
D5S818
10,12
D7S820
11
TH01
6,9
TPOX
8
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.
Cancer Res. 65:7276-7282(2005).