RERF-LC-Sq1Homo sapiens (Human)Cancer cell line

Also known as: Radiation Effects Research Foundation-Lung Cancer-Squamous 1, RERFLCSq1, RERFLCSQ1, RERF-LC-Sq-1

🤖 AI SummaryBased on 6 publications

Quick Overview

Human squamous cell lung cancer cell line with EGFR mutations and genetic heterogeneity.

Detailed Summary

RERF-LC-Sq1 is a human squamous cell lung cancer cell line derived from Japanese patients. It exhibits genetic heterogeneity in EGFR mutations, with some subpopulations showing specific mutations. This cell line is used in studies related to lung cancer, particularly in understanding the role of EGFR mutations in drug sensitivity and resistance. Research has identified multiple EGFR mutations, including L858R and E746-A750del, which are associated with responses to targeted therapies. The cell line is also part of broader cancer research efforts to identify predictive biomarkers for treatment outcomes.

Research Applications

EGFR mutation analysisDrug sensitivity profilingGenetic heterogeneity studies

Key Characteristics

Presence of EGFR mutationsSubpopulation genetic heterogeneityRelevance to lung cancer research

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1656
Species	Homo sapiens (Human)
Tissue Source	Lung[UBERON:UBERON_0002048]

Donor Information

Age	74
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Lung squamous cell carcinoma
Lineage	Lung
Subtype	Lung Squamous Cell Carcinoma
OncoTree Code	LUSC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000442_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	PIK3CA	p.Glu545Lys (c.1633G>A)	Heterozygous	-	from parent cell line MCF-7

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

9,11

D13S317

D16S539

9,11

D5S818

D7S820

11,12

TH01

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.

Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.

Br. J. Cancer 109:1599-1608(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.

Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.

Cancer Res. 65:7276-7282(2005).

DOI PubMed