Rh18Homo sapiens (Human)Cancer cell line
Also known as: SJRH18, SJRH-18, Rh 18, Rh-18, RH-18, RH18
Quick Overview
Human rhabdomyosarcoma cell line with alveolar subtype characteristics.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1659 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Perineus, muscle[UBERON:UBERON_0002379] |
Donor Information
| Age | 2 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
Disease Information
| Disease | Alveolar rhabdomyosarcoma |
|---|---|
| Lineage | Soft Tissue |
| Subtype | Embryonal Rhabdomyosarcoma |
| OncoTree Code | ERMS |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000689_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationNone reported | TP53 | - | - | - | PubMed=19787792 |
| Gene fusion | FOXO1 | PAX3-FOXO1, PAX3-FKHR | - | Not found in original tumor | from parent cell line Rh30 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Surfaceome profiling of cell lines and patient-derived xenografts confirm FGFR4, NCAM1, CD276, and highlight AGRL2, JAM3, and L1CAM as surface targets for rhabdomyosarcoma.
Sala R., Heller M., Rossler J., Bernasconi M.
Int. J. Mol. Sci. 24:2601.1-2601.28(2023).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Assessing alveolar rhabdomyosarcoma cell lines as tumor models by comparison of mRNA expression profiles.
Batchu S., Kellish A.S., Hakim A.A.
Gene 760:145025.1-145025.5(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Harris E., Monks A., Morris J.
Mol. Cancer Ther. 14:2452-2462(2015).
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Linardic C.M.
Front. Oncol. 3:183.1-183.12(2013).
Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array.
Ogawa S.
Cancer Sci. 104:856-864(2013).
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Reynolds C.P.
Pediatr. Blood Cancer 56:239-249(2011).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development.
Pritchard-Jones K., Kool M., Shipley J.M.
Genes Chromosomes Cancer 48:455-467(2009).
Pediatric rhabdomyosarcoma cell lines are resistant to Fas-induced apoptosis and highly sensitive to TRAIL-induced apoptosis.
Petak I., Douglas L., Tillman D.M., Vernes R., Houghton J.A.
Clin. Cancer Res. 6:4119-4127(2000).
Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays.
Smith P.D., Jiang Y., Gooden G.C., Trent J.M., Meltzer P.S.
Cancer Res. 58:5009-5013(1998).
Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status.
Harris L.C.
Oncol. Res. 10:235-244(1998).
Deficiency in rhabdomyosarcomas of a factor required for MyoD activity and myogenesis.
Tapscott S.J., Thayer M.J., Weintraub H.M.
Science 259:1450-1453(1993).
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
Rauscher F.J. 3rd, Emanuel B.S., Rovera G., Barr F.G.
Nat. Genet. 5:230-235(1993).
Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization.
Biegel J.A., Nycum L.M., Valentine V.A., Barr F.G., Shapiro D.N.
Genes Chromosomes Cancer 12:186-192(1995).
Growth and characterization of childhood rhabdomyosarcomas as xenografts.
Houghton J.A., Houghton P.J., Webber B.L.
J. Natl. Cancer Inst. 68:437-443(1982).
Characterization of cell lines derived from xenografts of childhood rhabdomyosarcoma.
Torrance P.M., Holt H., Houghton P.J.
Cancer Res. 47:4501-4507(1987).