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RPMI-8402Homo sapiens (Human)Cancer cell line

Also known as: 8402, Roswell Park Memorial Institute 8402, RPMI8402, RPMI 8402

🤖 AI SummaryBased on 12 publications

Quick Overview

Human T-cell acute lymphoblastic leukemia cell line for cancer research.

Detailed Summary

RPMI-8402 is a human T-cell acute lymphoblastic leukemia (T-ALL) cell line derived from peripheral blood. It is characterized by CD3- T-cell phenotype and is used in studies related to T-cell receptor (TCR) gene rearrangements and molecular diagnostics. The cell line has been utilized in research on JAK2 V617F mutations and has been part of large-scale genomic studies for cancer research. It is also noted for its genetic heterogeneity and is used in investigations of clonal evolution and drug sensitivity. RPMI-8402 is a valuable tool for understanding the molecular mechanisms of T-ALL and for developing targeted therapies.

Research Applications

Molecular diagnostics of T-cell receptor gene rearrangementsJAK2 V617F mutation studiesGenomic profiling for cancer researchClonal evolution and drug sensitivity analysisTargeted therapy development for T-cell malignancies

Key Characteristics

CD3- T-cell phenotypeGenetic heterogeneityExpresses TCRB, TCRG, and TCRD gene rearrangementsUsed in studies of clonal evolutionPart of large-scale genomic data sets like CCLE
Generated on 6/17/2025

Basic Information

Database IDCVCL_1667
SpeciesHomo sapiens (Human)
Tissue SourcePeripheral blood[UBERON:UBERON_0000178]

Donor Information

Age16
Age CategoryPediatric
SexFemale
Subtype FeaturesTAL1

Disease Information

DiseasePrecursor T-cell acute lymphoblastic leukemia
LineageLymphoid
SubtypeT-Lymphoblastic Leukemia/Lymphoma
OncoTree CodeTLL

DepMap Information

Source TypeDSMZ
Source IDACH-000636_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleWT1p.Ser121Ter (c.362C>A)Heterozygous-Unknown, PubMed=22675565
MutationSimpleTP53p.Arg273Cys (c.817C>T)Homozygous-PubMed=35933914
MutationSimplePTENp.Arg159Ser (c.477G>T)Homozygous-Unknown
MutationSimpleNOTCH1p.Glu1583_Gln1584insProValGluLeuMetProProGlu (c.4750_4751insCCGTGGAGCTGATGCCGCCGGAGC)Heterozygous-PubMed=15472075
MutationSimpleFBXW7p.Arg465His (c.1394G>A)Homozygous-Unknown, PubMed=26870252, PubMed=22675565
Gene fusionSTILSTIL-TAL1, SIL-TAL1, SIL-SCL--PubMed=29496689, PubMed=2255914
Gene fusionLMO1LMO1-TRD--PubMed=29496689, PubMed=2501659

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11,12
D13S317
11,12
D16S539
10,11
D18S51
16,20
D19S433
12,13,14
D21S11
30
D2S1338
19,23
D3S1358
14,16
D5S818
12,13
D7S820
8,13
D8S1179
11
FGA
23
Penta D
9,11
Penta E
7,14
TH01
9,9.3
TPOX
8
vWA
14,20
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOIPubMedPMC

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOIPubMedPMC

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOIPubMedPMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOIPubMedPMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOIPubMedPMC

Characterization of camptothecin-induced genomic changes in the camptothecin-resistant T-ALL-derived cell line CPT-K5.

Stougaard M., Knudsen B.R.

Cancer Genomics Proteomics 15:91-114(2018).

DOIPubMedPMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOIPubMedPMC

Genetic heterogeneity of RPMI-8402, a T-acute lymphoblastic leukemia cell line.

Peciak J.D., Hulas-Bigoszewska K., Winiecka-Klimek M., Rieske P.

Oncol. Lett. 11:593-599(2016).

DOIPubMedPMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOIPubMedPMC

High accuracy mutation detection in leukemia on a selected panel of cancer genes.

Cools J., Aerts S.

PLoS ONE 7:E38463-E38463(2012).

DOIPubMedPMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOIPubMedPMC

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Langerak A.W.

Leukemia 21:230-237(2007).

DOIPubMed

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOIPubMed

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.

Science 306:269-271(2004).

DOIPubMed

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

DOIPubMed

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

DOIPubMed

Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.

Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.

Leuk. Res. 23:19-27(1999).

DOIPubMed

Cytogenetic study of human lymphoid T-cell lines derived from lymphocytic leukemia.

Huang C.C., Hou Y., Woods L.K., Moore G.E., Minowada J.

J. Natl. Cancer Inst. 53:655-660(1974).

DOIPubMed

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

DOIPubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOIPubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

DOIPubMed

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

Okada K.

Proc. Natl. Acad. Sci. U.S.A. 84:5565-5569(1987).

DOIPubMedPMC

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

DOIPubMed

The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein.

O'Brien S.J., Korsmeyer S.J.

Mol. Cell. Biol. 9:2124-2132(1989).

DOIPubMedPMC

Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity.

Kirsch I.R.

Science 250:1426-1429(1990).

DOIPubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Cell lines from humans with hematopoietic malignancies.";

Moore G.E.

(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.299-331; Springer; New York; USA (1975).

DOI