RVH-421Homo sapiens (Human)Cancer cell line

Also known as: RVH421, RVH 421

🤖 AI SummaryBased on 4 publications

Quick Overview

Human cell line derived from unknown tissue, used in cancer research.

Detailed Summary

RVH-421 is a human cell line with unknown tissue origin and disease context. It is utilized in cancer research, particularly in studies involving genetic and molecular profiling. The cell line is part of large-scale cancer cell line databases, contributing to research on drug sensitivity and genomic alterations. However, specific details about its tissue of origin, disease type, and cell type remain unspecified in the available data.

Research Applications

Cancer researchGenomic profilingDrug sensitivity studies

Key Characteristics

Part of large cancer cell line databasesUsed for molecular and genetic studies

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1672
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	28
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Melanoma
Lineage	Skin
Subtype	Melanoma
OncoTree Code	MEL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000614_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gln52fs*71 (c.154delC)	Heterozygous	-	from parent cell line RVH-421
MutationSimple	TERT	c.1-146C>T (c.250C>T) (C250T)	Unspecified	In promoter	PubMed=31068700
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

D16S539

9,11

D18S51

15,16

D19S433

14,16

D21S11

29,30

D2S1338

19,25

D3S1358

16,17

D5S818

10,14

D7S820

7,10

D8S1179

13,14

FGA

21,22

Penta D

9,13

Penta E

TH01

9.3

TPOX

vWA

14,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed

The establishment and characterization of a cell line and mouse xenografts from a human malignant melanoma.

McCormick D., Wallace I.J.C., Kirk J., Dinsmore S., Allen I.V.

Br. J. Exp. Pathol. 64:103-115(1983).

PubMed PMC