S-117Homo sapiens (Human)Cancer cell line
Also known as: CLS-117, S117
🤖 AI SummaryBased on 5 publications
Quick Overview
Human cancer cell line with unknown tissue and disease origins.
Detailed Summary
The S-117 cell line is a human-derived cancer cell line with unknown tissue and disease origins. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been characterized in genomic and pharmacological studies. Research on S-117 focuses on understanding its genetic profile and drug sensitivity, contributing to the broader effort of predicting anticancer drug responses based on genomic data. The cell line's properties are part of large-scale studies aimed at identifying biomarkers for personalized cancer treatment.
Generated on 6/17/2025
Basic Information
| Database ID | CVCL_1674 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Thyroid gland[UBERON:UBERON_0002046] |
Donor Information
| Age | 47 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Thyroid gland sarcoma |
|---|---|
| Lineage | Soft Tissue |
| Subtype | Sarcoma, NOS |
| OncoTree Code | SARCNOS |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000037_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Glu326Ter (c.976G>T) | Homozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
13
D13S317
12
D16S539
11
D18S51
11
D19S433
14
D21S11
30
D2S1338
24
D3S1358
18
D5S818
11
D7S820
11
D8S1179
15
FGA
22
Penta D
10
Penta E
18
TH01
6
TPOX
8
vWA
14
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Screening human cell lines for viral infections applying RNA-Seq data analysis.
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
PLoS ONE 14:E0210404-E0210404(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).