SASHomo sapiens (Human)Cancer cell line

🤖 AI SummaryBased on 9 publications

Quick Overview

Human oral squamous cell carcinoma cell line with high metastatic potential.

Detailed Summary

The SAS cell line is a human oral squamous cell carcinoma cell line derived from a poorly differentiated tumor. It exhibits high metastatic potential, particularly to cervical lymph nodes. Research has shown that SAS cells have increased migratory and invasive abilities compared to other cell lines. The cell line is used in studies related to cancer metastasis, genetic alterations, and therapeutic target identification. It has been utilized in investigations of tumor suppressor genes like FAT and in understanding the mechanisms of cell adhesion and signaling pathways. The SAS cell line is also employed in drug screening and in studying the effects of genetic modifications on cancer progression.

Research Applications

Cancer metastasis studiesGenetic alteration analysisTherapeutic target identificationTumor suppressor gene researchCell adhesion and signaling pathway studiesDrug screening

Key Characteristics

High metastatic potentialIncreased migratory and invasive abilitiesUsed in studies of tumor suppressor genes like FATEmployed in drug screening and genetic modification research

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1675
Species	Homo sapiens (Human)
Tissue Source	Oral cavity, tongue[UBERON:UBERON_0001723]

Donor Information

Age	69
Age Category	Adult
Sex	Female

Disease Information

Disease	Squamous cell carcinoma of the oral tongue
Lineage	Head and Neck
Subtype	Oral Cavity Squamous Cell Carcinoma
OncoTree Code	OCSC

DepMap Information

Source Type	RIKEN
Source ID	ACH-002029_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Glu336Ter (c.1006G>T)	Homozygous	-	from parent cell line SN12C-PM6

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

10,12

D16S539

12,13

D18S51

D21S11

D3S1358

16,17

D5S818

D7S820

11,12

D8S1179

11,13

FGA

Penta D

10,13

Penta E

5,20

TH01

6,7

TPOX

11,12

vWA

10,14

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.

McDermott U., Garnett M.J., Cheong S.-C.

eLife 9:e57761.1-e57761.34(2020).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Biological characterization and analysis of metastasis-related genes in cell lines derived from the primary lesion and lymph node metastasis of a squamous cell carcinoma arising in the mandibular gingiva.

Ikari T., Onimaru M., Akimoto N., Jogo R., Mori Y.

Int. J. Oncol. 44:1614-1624(2014).

DOI PubMed

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.

Hamakawa H.

Oncogene 26:5300-5308(2007).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.

Itoh K.

Cell. Immunol. 177:176-181(1997).

DOI PubMed

HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.

Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.

Cell. Immunol. 175:101-110(1997).

DOI PubMed

Establishment and characterization of a cell line (SAS) from poorly differentiated human squamous cell carcinoma of the tongue.

Muto T., Tanzawa H., Sato K.-i.

J. Jpn. Stomatol. Soc. 38:20-28(1989).

DOI

Establishment and charactalization of human oral squamous cell carcinoma cell line with highly lymph node metastatic potential.

Aida T., Irie T., Tachikawa T.

J. Jpn. Soc. Oral Oncol. 13 Suppl. 1:301-306(2001).

DOI