Titanovo Logo
Back to Cell Types

SCC-15Homo sapiens (Human)Cancer cell line

Also known as: SCC15, SCC 15

🤖 AI SummaryBased on 12 publications

Quick Overview

Human squamous cell carcinoma cell line with methotrexate resistance mechanisms studied.

Detailed Summary

SCC-15 is a human squamous cell carcinoma cell line derived from a tongue carcinoma, widely used in cancer research. It exhibits multiple mechanisms of methotrexate resistance, including decreased transport, polyglutamation defects, and increased dihydrofolate reductase (DHFR) levels. Research on SCC-15 has provided insights into the biochemical basis of drug resistance in head and neck cancers. The cell line is also utilized in studies examining the role of p53 mutations and their correlation with cancer progression. Additionally, SCC-15 has been part of genomic and proteomic analyses to understand molecular alterations in cancer development and therapeutic responses.

Research Applications

Methotrexate resistance mechanismsp53 mutation analysisGenomic and proteomic profilingDrug sensitivity and resistance studies

Key Characteristics

Methotrexate-resistantp53 mutations presentIncreased DHFR expressionUsed in cancer drug development
Generated on 6/17/2025

Basic Information

Database IDCVCL_1681
SpeciesHomo sapiens (Human)
Tissue SourceOral cavity, tongue[UBERON:UBERON_0001723]

Donor Information

Age55
Age CategoryAdult
SexMale

Disease Information

DiseaseSquamous cell carcinoma of the oral tongue
LineageHead and Neck
SubtypeOral Cavity Squamous Cell Carcinoma
OncoTree CodeOCSC

DepMap Information

Source TypeATCC
Source IDACH-000254_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
10,13
D13S317
9,14
D16S539
12,15
D18S51
16
D19S433
15
D21S11
30
D2S1338
16,23
D3S1358
16
D5S818
12
D7S820
10,11
D8S1179
10,13
FGA
19,24
Penta D
9
Penta E
7,13
TH01
9,9.3
TPOX
8
vWA
15,17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOIPubMedPMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOIPubMedPMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.

Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.

Oncotarget 8:86369-86383(2017).

DOIPubMedPMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOIPubMedPMC

Tumor growth and cell proliferation rate in human oral cancer.";

Gavish A., Krayzler E., Nagler R.

Arch. Med. Res. 47:271-274(2016).

DOIPubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOIPubMedPMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOIPubMedPMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOIPubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOIPubMed

The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.

Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.

Oncotarget 5:8906-8923(2014).

DOIPubMedPMC

MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin gamma2 expression in oral dysplasia and squamous cell carcinoma.

Degen M., Natarajan E., Barron P., Widlund H.R., Rheinwald J.G.

Am. J. Pathol. 180:2462-2478(2012).

DOIPubMedPMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.

Clin. Cancer Res. 17:7248-7264(2011).

DOIPubMedPMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOIPubMedPMC

Integrative molecular characterization of head and neck cancer cell model genomes.

Tsui I.F.L., Garnis C.

Head Neck 32:1143-1160(2010).

DOIPubMedPMC

Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.

Koch W.M., Ferris R.L., Lai S.Y.

Head Neck 29:163-188(2007).

DOIPubMed

Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.

Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.

Br. J. Cancer 67:1274-1284(1993).

DOIPubMedPMC

Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.

Rheinwald J.G., Beckett M.A.

Cancer Res. 41:1657-1663(1981).

PubMed

Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture.

Ervin T.J., Jolivet J., Haseltine W.A.

Proc. Natl. Acad. Sci. U.S.A. 81:2873-2877(1984).

DOIPubMedPMC

The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia.

Griffiths C.T., Rheinwald J.G.

Cell 31:693-703(1982).

DOIPubMed

Multiparametric flow cytometry of human squamous cell carcinoma lines from the head and neck.

Wustrow T.P.U., Raffael A., Valet G.K.

Otolaryngol. Head Neck Surg. 98:552-557(1988).

DOIPubMed

Frequent p53 mutations in head and neck cancer.";

Casey G.

Cancer Res. 52:5997-6000(1992).

PubMed

Head and neck tumor cell lines.";

Carey T.E.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).

DOI

Web Resources

tcpaportal.orgatcc.org