SCC-25Homo sapiens (Human)Cancer cell line
Also known as: SCC 25, SCC25, hSCC-25, SCCS-25
Quick Overview
Human head and neck squamous cell carcinoma cell line with known radioresistance and genetic alterations.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1682 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, tongue[UBERON:UBERON_0001723] |
Donor Information
| Age | 70 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Tongue squamous cell carcinoma |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000188_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg209Lysfs*6 (c.626_627delGA) | Heterozygous | - | from parent cell line SCC-25 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Head and neck tumor cell lines.";
Carey T.E.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
Dunphy E.J., Beckett M.A., Thompson L.H., Weichselbaum R.R.
Radiat. Res. 130:166-170(1992).
The interaction between recombinant human tumor necrosis factor and radiation in 13 human tumor cell lines.
Hallahan D.E., Beckett M.A., Kufe D.W., Weichselbaum R.R.
Int. J. Radiat. Oncol. Biol. Phys. 19:69-74(1990).
Radiobiological characterization of 53 human tumor cell lines.";
Weichselbaum R.R., Rotmensch J., Ahmed-Swan S., Beckett M.A.
Int. J. Radiat. Biol. 56:553-560(1989).
Faster repair of DNA double-strand breaks in radioresistant human tumor cells.
Weichselbaum R.R.
Int. J. Radiat. Oncol. Biol. Phys. 15:907-912(1988).
Multiparametric flow cytometry of human squamous cell carcinoma lines from the head and neck.
Wustrow T.P.U., Raffael A., Valet G.K.
Otolaryngol. Head Neck Surg. 98:552-557(1988).
Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy.
Weichselbaum R.R., Beckett M.A., Schwartz J.L., Dritschilo A.
Int. J. Radiat. Oncol. Biol. Phys. 15:575-579(1988).
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
Clark J., Ervin T.J.
Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986).
Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).
Rosowsky A., Henner W.D., Frei E. 3rd
Cancer Res. 47:388-393(1987).
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
Hellman S., Rheinwald J.G.
Br. J. Cancer 49:595-601(1984).
Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.
Rheinwald J.G., Beckett M.A.
Cancer Res. 41:1657-1663(1981).
p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.
Weichselbaum R.R.
Cancer Res. 53:3667-3669(1993).
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.
Br. J. Cancer 67:1274-1284(1993).
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Koch W.M., Ferris R.L., Lai S.Y.
Head Neck 29:163-188(2007).
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Hamakawa H.
Oncogene 26:5300-5308(2007).
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Yarbrough W.G., Whigham A., Brown B., Roach M., Slebos R.J.C.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007).
Integrative molecular characterization of head and neck cancer cell model genomes.
Tsui I.F.L., Garnis C.
Head Neck 32:1143-1160(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Clin. Cancer Res. 17:7248-7264(2011).
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
Spellman P.T., South A.P., Aster J.C., Blacklow S.C., Cho R.J.
Proc. Natl. Acad. Sci. U.S.A. 108:17761-17766(2011).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin gamma2 expression in oral dysplasia and squamous cell carcinoma.
Degen M., Natarajan E., Barron P., Widlund H.R., Rheinwald J.G.
Am. J. Pathol. 180:2462-2478(2012).
FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis.
Goldie S.J., Mulder K.W., Tan D.W.-M., Lyons S.K., Sims A.H., Watt F.M.
Cancer Res. 72:3424-3436(2012).
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Symer D.E., Gillison M.L.
Genome Res. 24:185-199(2014).
Regulation of estrogen receptor alpha function in oral squamous cell carcinoma cells by FAK signaling.
Hsiao Y.-H., Luo F.-J., Yuan T.-C.
Endocr. Relat. Cancer 21:555-565(2014).
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
Oncotarget 5:8906-8923(2014).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma.
Simons A.L.
Mol. Oncol. 9:1371-1383(2015).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Tumor growth and cell proliferation rate in human oral cancer.";
Gavish A., Krayzler E., Nagler R.
Arch. Med. Res. 47:271-274(2016).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
Epithelial-mesenchymal crosstalk induces radioresistance in HNSCC cells.
Riechelmann H., Dudas J., Skvortsova I.-I.
Oncotarget 9:3641-3652(2018).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Nat. Commun. 10:3574.1-3574.11(2019).