SCC-3Homo sapiens (Human)Cancer cell line

Also known as: SCC3

🤖 AI SummaryBased on 7 publications

Quick Overview

Human cancer cell line with potential for studying cancer genetics and drug responses.

Detailed Summary

SCC-3 is a human cancer cell line derived from a patient with non-Hodgkin's lymphoma. It expresses the interleukin-2 receptor (IL2-R) and is characterized as a monocytic cell line. Research on SCC-3 has focused on understanding the role of IL2-R in monocytic cells and its implications in cancer biology. The cell line has been used to study the effects of mutations on protein expression and drug sensitivity, particularly in the context of cancer immunotherapy. SCC-3 has also been involved in studies related to viral infections and their impact on cancer cell behavior. Its utility in identifying neo-epitopes and understanding HLA class I and II interactions makes it a valuable resource for cancer research.

Research Applications

Cancer immunotherapyViral infection studiesHLA class I and II interactionsNeo-epitope identificationDrug sensitivity profiling

Key Characteristics

Expresses IL2-RMonocytic lineageUsed in mutation and protein expression studiesRelevance to cancer genetics

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1683
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	20
Age Category	Adult
Sex	Female

Disease Information

Disease	B-cell non-Hodgkin lymphoma
Lineage	Lymphoid
Subtype	Mature B-Cell Neoplasms
OncoTree Code	MBN

DepMap Information

Source Type	JCRB
Source ID	ACH-001642_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

11,12

D18S51

13,18

D21S11

D3S1358

D5S818

D7S820

11,12

D8S1179

FGA

Penta D

11,14

Penta E

17,19

TH01

8,9

TPOX

9,11

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.

Quentmeier H., Drexler H.G.

Leukemia 10:142-149(1996).

PubMed

Establishment and characterization of a monocytic cell line which expresses the interleukin-2 receptor.

Kimura Y., Toki H., Okabe K.-i., Suzuki K.-i., Hayakawa T., Miyamoto K.

Jpn. J. Cancer Res. 77:862-865(1986).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

tcpaportal.org