SCC-4Homo sapiens (Human)Cancer cell line
Also known as: SCC4, SCC 4
Quick Overview
Human squamous cell carcinoma cell line for cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1684 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, tongue[UBERON:UBERON_0001723] |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral tongue |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000238_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Pro151Ser (c.451C>T) | Unspecified | Somatic mutation acquired during proliferation | PubMed=28445466 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.
Hart C.P., Print C.G., Wilson W.R., Curran M.A., Hunter F.W.
JCI Insight 3:e122204.1-e122204.19(2018).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Regulation of estrogen receptor alpha function in oral squamous cell carcinoma cells by FAK signaling.
Hsiao Y.-H., Luo F.-J., Yuan T.-C.
Endocr. Relat. Cancer 21:555-565(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
Spellman P.T., South A.P., Aster J.C., Blacklow S.C., Cho R.J.
Proc. Natl. Acad. Sci. U.S.A. 108:17761-17766(2011).
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Clin. Cancer Res. 17:7248-7264(2011).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells.
Sonenberg N., Lotan R.
Cancer Prev. Res. (Philadelphia) 3:331-338(2010).
Integrative molecular characterization of head and neck cancer cell model genomes.
Tsui I.F.L., Garnis C.
Head Neck 32:1143-1160(2010).
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Koch W.M., Ferris R.L., Lai S.Y.
Head Neck 29:163-188(2007).
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.
Br. J. Cancer 67:1274-1284(1993).
Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.
Rheinwald J.G., Beckett M.A.
Cancer Res. 41:1657-1663(1981).
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
Hellman S., Rheinwald J.G.
Br. J. Cancer 49:595-601(1984).
The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia.
Griffiths C.T., Rheinwald J.G.
Cell 31:693-703(1982).
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
Clark J., Ervin T.J.
Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986).
Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy.
Weichselbaum R.R., Beckett M.A., Schwartz J.L., Dritschilo A.
Int. J. Radiat. Oncol. Biol. Phys. 15:575-579(1988).
Radiobiological characterization of 53 human tumor cell lines.";
Weichselbaum R.R., Rotmensch J., Ahmed-Swan S., Beckett M.A.
Int. J. Radiat. Biol. 56:553-560(1989).
Head and neck tumor cell lines.";
Carey T.E.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).