SF126Homo sapiens (Human)Cancer cell line

Also known as: SF 126, SF-126

🤖 AI SummaryBased on 11 publications

Quick Overview

Human glioblastoma cell line with known genetic alterations and drug resistance profiles.

Detailed Summary

SF126 is a human glioblastoma cell line derived from a malignant glioma. It exhibits specific genetic alterations, including homozygous deletions in genes such as PARD3, which are associated with cancer progression. The cell line is resistant to certain chemotherapeutic agents like BCNU, showing increased repair of DNA lesions. SF126 is used in research to study mechanisms of drug resistance and tumor biology, particularly in the context of glioblastoma multiforme. Its characteristics make it a valuable model for investigating the molecular mechanisms underlying glioma development and therapeutic responses.

Research Applications

Cancer researchDrug resistance mechanismsGenetic alterations in glioblastomaDNA repair mechanisms

Key Characteristics

Resistance to BCNUHomozygous deletions in PARD3Used in studying DNA repair and drug resistance
Generated on 6/17/2025

Basic Information

Database IDCVCL_1688
SpeciesHomo sapiens (Human)
Tissue SourceBrain, left frontal lobe[UBERON:UBERON_0002811]

Donor Information

Age50
Age CategoryAdult
SexFemale

Disease Information

DiseaseGlioblastoma
LineageCNS/Brain
SubtypeGlioblastoma
OncoTree CodeGB

DepMap Information

Source TypeHSRRB
Source IDACH-000609_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Pro75Hisfs*13 (c.224_750del)Heterozygous-Unknown
MutationSimplePTENp.Gly129Arg (c.385G>A)Homozygous-Unknown
MutationSimpleATRp.Arg1653Ter (c.4957C>T)Heterozygous-Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12
D13S317
11
D16S539
9,12
D18S51
13,19
D19S433
13,14
D21S11
27,32.2
D2S1338
16,17
D3S1358
17,18
D5S818
11
D7S820
8,10
D8S1179
12,13
FGA
21,24
Penta D
10,14
Penta E
12,13
TH01
6,7
TPOX
8,11
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Aoyagi M., Ohno K., Imoto I., Inazawa J.

Cancer Sci. 96:676-683(2005).

Increased repair of O6-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea.

Bodell W.J., Aida T., Berger M.S., Rosenblum M.L.

Carcinogenesis 7:879-883(1986).

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.

Cancer Res. 48:589-601(1988).

Establishment and characterization of five cell lines derived from human malignant gliomas.

Bell C.W., Stern R.S., Wilson C.B., Rosenblum M.L.

Acta Neuropathol. 75:92-103(1987).

Human glioma cell lines.";

Nister M., Westermark B.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York; USA (1994).

Brain tumors.";

Ali-Osman F.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).