SK-N-DZHomo sapiens (Human)Cancer cell line

Also known as: SKNDZ

🤖 AI SummaryBased on 13 publications

Quick Overview

Human neuroblastoma cell line with potential for research in cancer biology and drug sensitivity.

Detailed Summary

SK-N-DZ is a human neuroblastoma cell line derived from a neuroblastoma tumor. It is used in research to study the molecular mechanisms of neuroblastoma, including genetic alterations, drug sensitivity, and cellular responses to treatments. This cell line has been utilized in studies involving transcriptomic profiling, identification of mutations, and evaluation of therapeutic targets. Its characteristics make it a valuable model for understanding neuroblastoma progression and developing targeted therapies. Additionally, SK-N-DZ has been examined for its response to 13-cis-retinoic acid, showing unique sensitivity compared to other cell lines.

Research Applications

Transcriptomic profilingMutation analysisDrug sensitivity testingCancer biology research

Key Characteristics

Sensitivity to 13-cis-retinoic acidUsed in studies of neuroblastoma progressionPotential for identifying therapeutic targets

Generated on 6/17/2025

Basic Information

Database ID	CVCL_1701
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	2
Age Category	Pediatric
Sex	Female
Race	caucasian
Subtype Features	MYC_Amplified

Disease Information

Disease	Neuroblastoma
Lineage	Peripheral Nervous System
Subtype	Neuroblastoma
OncoTree Code	NBL

DepMap Information

Source Type	ATCC
Source ID	ACH-000366_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg110Leu (c.329G>T)	Unspecified	-	PubMed=10741724, PubMed=7732013

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

8,11

D16S539

9,11

D18S51

15,17

D19S433

14.2,16

D21S11

29,31

D2S1338

21,22,23

D3S1358

D5S818

D7S820

12,13

D8S1179

12,13

FGA

18,22

Penta D

9,14

Penta E

7,10

TH01

6,9

TPOX

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.

Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.

Sci. Data 4:170033-170033(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Identification of ALK as a major familial neuroblastoma predisposition gene.

Maris J.M.

Nature 455:930-935(2008).

DOI PubMed PMC

Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.

Hayashi Y.

J. Pediatr. Surg. 42:2040-2045(2007).

DOI PubMed

Mutations in PIK3CA are infrequent in neuroblastoma.";

Dam V., Morgan B.T., Mazanek P., Hogarty M.D.

BMC Cancer 6:177.1-177.10(2006).

DOI PubMed PMC

PPM1D is a potential target for 17q gain in neuroblastoma.";

Sugimoto T., Inazawa J.

Cancer Res. 63:1876-1883(2003).

PubMed

Determination of cell surface membrane antigens common to both human neuroblastoma and leukemia-lymphoma cell lines by a panel of 38 monoclonal antibodies.

Minowada J.

J. Natl. Cancer Inst. 73:51-57(1984).

DOI PubMed

Human neuroblastoma cells and 13-cis-retinoic acid.";

Helson L., Helson C.

J. Neurooncol. 3:39-41(1985).

DOI PubMed

Vitamin E and human neuroblastoma.";

Helson L., Verma M., Helson C.

(In book chapter) Modulation and mediation of cancer by vitamins; Meyskens F.L., Prasad K.N. (eds.); pp.258-265; Karger; Basel; Switzerland (1983).

DOI

Tumor cell lines of the peripheral nervous system.";

Israel M.A., Thiele C.J.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).

DOI